Rehm J, Samokhvalov AV, Shield KD (2013) Global burden of alcoholic liver diseases. J Hepatol 59(1):160–168
Article
PubMed
Google Scholar
Basyte-Bacevice V, Skieceviciene J, Valantiene I, Sumskiene J, Petrenkiene V, Kondrackiene J, Kupcinskas J (2019) TM6SF2 and MBOAT7 gene variants in liver fibrosis and cirrhosis. Int J Mol Sci 20(6):1277
Article
CAS
PubMed Central
Google Scholar
Lieber CS, Jones DP, DeCarli LM (1965) Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J Clin Invest 44(6):1009–1021
Article
CAS
PubMed
PubMed Central
Google Scholar
Lieber CS, Decarli LM (1976) Animal models of ethanol dependence and liver injury in rats and baboons. In Fed Proc 35(5):1232–1236
CAS
Google Scholar
Brandon-Warner E, Schrum LW, Schmidt CM, McKillop IH (2012) Rodent models of alcoholic liver disease: of mice and men. Alcohol 46(8):715–725
Article
PubMed
PubMed Central
Google Scholar
Bellentani S, Saccoccio G, Costa G, Tiribelli C, Manenti F, Sodde M, Dionysos Study Group (1997) Drinking habits as cofactors of risk for alcohol induced liver damage. Gut 41(6):845–850
Article
CAS
PubMed
PubMed Central
Google Scholar
Becker U, Deis A, Sorensen TI, Gronbaek M, Borch-Johnsen K, Muller CF, Jensen G (1996) Prediction of risk of liver disease by alcohol intake, sex, and age: a prospective population study. Hepatology 23(5):1025–1029
Article
CAS
PubMed
Google Scholar
Fattovich G, Giustina G, Degos F, Tremolada F, Diodati G, Almasio P, Realdi G (1997) Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology 112(2):463–472
Article
CAS
PubMed
Google Scholar
Teli MR, Day CP, James OFW, Burt AD, Bennett MK (1995) Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet 346(8981):987–990
Article
CAS
PubMed
Google Scholar
Bellentani S, Tiribelli C, Saccoccio G, Sodde M, Fratti N, De Martin C, Christianini G (1994) Prevalence of chronic liver disease in the general population of northern Italy: the Dionysos study. Hepatology 20(6):1442–1449
Article
CAS
PubMed
Google Scholar
Lieber CS (1988) Biochemical and molecular basis of alcohol-induced injury to liver and other tissues. N Engl J Med 319(25):1639–1650
Article
CAS
PubMed
Google Scholar
Mendenhall CL, Anderson S, Weesner RE, Goldberg SJ, Crolic KA (1984) Protein-calorie malnutrition associated with alcoholic hepatitis: veterans administration cooperative study group on alcoholic hepatitis. Am J Med 76(2):211–222
Article
CAS
PubMed
Google Scholar
Hirschhorn JN, Gajdos ZK (2011) Genome-wide association studies: results from the first few years and potential implications for clinical medicine. Annu Rev Med 62:11–24
Article
CAS
PubMed
Google Scholar
Sato N, Lindros KO, Baraona E, Ikejima K, Mezey E, Järveläinen HA, Ramchandani VA (2001) Sex difference in alcohol-related organ injury. Alcohol Clin Exp Res 25:40S–45S
Article
CAS
PubMed
Google Scholar
Stinson FS, Grant BF, Dufour MC (2001) The critical dimension of ethnicity in liver cirrhosis mortality statistics. Alcohol Clin Exp Res 25(8):1181–1187
Article
CAS
PubMed
Google Scholar
Reed T, Page WF, Viken RJ, Christian JC (1996) Genetic predisposition to organ-specific endpoints of alcoholism. Alcohol Clin Exp Res 20(9):1528–1533
Article
CAS
PubMed
Google Scholar
Hrubec Z, Omenn GS (1981) Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol Clin Exp Res 5(2):207–215
Article
CAS
PubMed
Google Scholar
Novo-Veleiro I, Cieza-Borrella C, Pastor I, Chamorro AJ, Laso FJ, Gonzalez-Sarmiento R, Marcos M (2016) A single nucleotide polymorphism in the RASGRF2 gene is associated with alcoholic liver cirrhosis in men. PLoS One 11(12):e0168685
Article
PubMed
PubMed Central
Google Scholar
Chang B, Hao S, Zhang L, Gao M, Sun Y, Huang A, Zou Z (2018) Association between aldehyde dehydrogenase 2 Glu504Lys polymorphism and alcoholic liver disease. Am J Med Sci 356(1):10–14
Article
PubMed
PubMed Central
Google Scholar
Nunes dos Santos K, Florentino RM, França A, Lima Filho ACM, Santos MLD, Missiaggia D, Leite MF (2019) Polymorphism in the promoter region of NFE2L2 gene is a genetic marker of susceptibility to cirrhosis associated with alcohol abuse. Int J Mol Sci 20(14):3589
Article
CAS
PubMed Central
Google Scholar
Li D, Zhao H, Gelernter J (2011) Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases. Biol Psychiatry 70(6):504–512
Article
CAS
PubMed
PubMed Central
Google Scholar
Kolla BP, Schneekloth TD, Biernacka J, Shah V, Lazaridis KN, Geske J, Karpyak V (2018) Pnpla3 association with alcoholic liver disease in a cohort of heavy drinkers. Alcohol Alcohol 53(4):357–360
Article
CAS
PubMed
PubMed Central
Google Scholar
Prasad P, Ambekar A, Vaswani M (2010) Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study. BMC Med Genet 11(1):1–8
Article
CAS
Google Scholar
Pineda-Tenor D, Gómez-Moreno AZ, Sánchez-Ruano JJ, Artaza-Varasa T, Virseda-Berdices A, Fernández-Rodríguez A, Resino S (2020) MTHFR rs1801133 polymorphism is associated with liver fibrosis progression in chronic hepatitis C: a retrospective study. Front Med (Lausanne) 7:582666
Tang S, Zhang J, Mei TT, Guo HQ, Wei XH, Zhang WY, Yu HB (2019) Association of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis. BMC Cancer 19(1):1–9
Article
Google Scholar
Takamatsu M, Yamauchi M, Maezawa Y, Saito S, Maeyama S, Uchikoshi T (2000) Genetic polymorphisms of interleukin-1β in association with the development of alcoholic liver disease in Japanese patients. Am J Gastroenterol 95(5):1305–1311
Article
CAS
PubMed
Google Scholar
Zeng T, Guo FF, Zhang CL, Song FY, Zhao XL, Xie KQ (2013) Roles of cytochrome P4502E1 gene polymorphisms and the risks of alcoholic liver disease: a meta-analysis. PLoS One 8(1):e54188
Article
CAS
PubMed
PubMed Central
Google Scholar
Pestka S, Langer JA, Zoon KC, Samuel CE (1987) Interferons and their actions. Annu Rev Biochem 56(1):727–777
Article
CAS
PubMed
Google Scholar
Coste I, Le Corf K, Kfoury A, Hmitou I, Druillennec S, Hainaut P, Renno T (2010) Dual function of MyD88 in RAS signaling and inflammation, leading to mouse and human cell transformation. J Clin Invest 120(10):3663–3667
Article
CAS
PubMed
PubMed Central
Google Scholar
Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D, Elliott P (2011) Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A 108(17):7119–7124
Article
CAS
PubMed
PubMed Central
Google Scholar
Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S, IMAGEN Consortium (2012) RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proc Natl Acad Sci U S A 109(51):21128–21133
Article
CAS
PubMed
PubMed Central
Google Scholar
Schwechter B, Rosenmund C, Tolias KF (2013) RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission. Proc Natl Acad Sci U S A 110(35):14462–14467
Article
CAS
PubMed
PubMed Central
Google Scholar
Tian X, Gotoh T, Tsuji K, Lo EH, Huang S, Feig LA (2004) Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk, and CREB. EMBO J 23(7):1567–1575
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Q, Siminovitch KA, Downey GP, McCulloch CA (2013) Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca2+ signalling, ERK activation and MMP-3 expression. Biochem J 449(3):771–782
Article
CAS
PubMed
Google Scholar
Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81(2):807–869
Article
CAS
PubMed
Google Scholar
Ma X, Espana-Serrano L, Kim WJ, Purayil HT, Nie Z, Daaka Y (2014) βArrestin1 regulates the guanine nucleotide exchange factor RasGRF2 expression and the small GTPase Rac-mediated formation of membrane protrusion and cell motility. J Biol Chem 289(19):13638–13650
Article
CAS
PubMed
PubMed Central
Google Scholar
Girault JA, Valjent E, Caboche J, Hervé D (2007) ERK2: a logical AND gate critical for drug-induced plasticity? Curr Opin Pharmacol 7(1):77–85
Article
CAS
PubMed
Google Scholar
Maiya R, Ponomarev I, Linse KD, Harris RA, Mayfield RD (2007) Defining the dopamine transporter proteome by convergent biochemical and in silico analyses. Genes Brain Behav 6(1):97–106
Article
CAS
PubMed
Google Scholar
Crabb DW, Matsumoto M, Chang D, You M (2004) Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 63(1):49–63
Article
CAS
PubMed
Google Scholar
Li D, Zhao H, Gelernter J (2012) Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (* 2) allele against alcoholism and alcohol-induced medical diseases in Asians. Hum Genet 131(5):725–737
Article
CAS
PubMed
Google Scholar
Yoshida A, Huang IY, Ikawa M (1984) Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci U S A 81(1):258–261
Article
CAS
PubMed
PubMed Central
Google Scholar
Whitfield JB, Martin NG (1993) Aversive reactions and alcohol use in Europeans. Alcohol Clin Exp Res 17(1):131–134
Article
CAS
PubMed
Google Scholar
Peterse EN (1992) The pharmacology and toxicology of disulfiram and its metabolites. Acta Psychiatr Scand Suppl 86(S369):7–13
Article
Google Scholar
Mizoi Y, Yamamoto K, Ueno Y, Fukunagai T, Harada S (1994) Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. Alcohol Alcohol 29(6):707–710
CAS
PubMed
Google Scholar
Edenberg HJ (2007) The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res Health 30(1):5
PubMed
PubMed Central
Google Scholar
Seitz HK, Stickel F (2006) Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 387(4):349–360
Article
CAS
PubMed
Google Scholar
Adeniji EA, Olotu FA, Soliman ME (2018) Alcohol metabolic inefficiency: structural characterization of polymorphism-induced ALDH2 dysfunctionality and allosteric site identification for design of potential wildtype reactivators. Protein J 37(3):216–222
Article
CAS
PubMed
Google Scholar
Stickel F, Datz C, Hampe J, Bataller R (2017) Pathophysiology and management of alcoholic liver disease: update 2016. Gut Liver 11(2):173
Article
CAS
PubMed
PubMed Central
Google Scholar
Magdaleno F, Blajszczak CC, Nieto N (2017) Key events participating in the pathogenesis of alcoholic liver disease. Biomolecules 7(1):9
Article
PubMed Central
Google Scholar
Zhang Y, Guo T, Yang F, Mao Y, Li L, Liu C, Huang J (2018) Single-nucleotide rs738409 polymorphisms in the PNPLA3 gene are strongly associated with alcoholic liver disease in Han Chinese males. Hepatol Int 12(5):429–437
Article
PubMed
Google Scholar
Anstee QM, Daly AK, Day CP (2015) Genetics of alcoholic liver disease. Semin Liver Dis 35(04):361–374 Thieme Medical Publishers
Article
CAS
PubMed
Google Scholar
Dharshini LCP, Vishnupriya S, Sakthivel KM, Rasmi RR (2020) Oxidative stress-responsive transcription factors in cellular signalling transduction mechanisms. Cell Signal 72:109670
Article
Google Scholar
Yoshida A, Hsu LC, Yasunami M (1991) Genetics of human alcohol-metabolizing enzymes. Prog Nucleic Acid Res Mol Biol 40:255–287
Article
CAS
PubMed
Google Scholar
Osier M, Pakstis AJ, Kidd JR, Lee JF, Yin SJ, Ko HC, Kidd KK (1999) Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism. Am J Hum Genet 64(4):1147–1157
Article
CAS
PubMed
PubMed Central
Google Scholar
Grant BF (1988) Dufour MC, and Harford TC. Epidemiology of alcoholic liver disease. Semin Liver Dis 8:12–25
Article
CAS
PubMed
Google Scholar
Dreiling DA, Koller M (1985) The natural history of alcoholic pancreatitis: update 1985. Mt Sinai J Med 52(5):340–342
CAS
PubMed
Google Scholar
Zintzaras E, Stefanidis I, Santos M, Vidal F (2006) Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Hepatology 43(2):352–361
Article
CAS
PubMed
Google Scholar
Yokoyama A, Yokoyama T, Matsui T, Mizukami T, Kimura M, Matsushita S, Maruyama K (2015) Alcohol dehydrogenase-1B (rs1229984) and aldehyde dehydrogenase-2 (rs671) genotypes are strong determinants of the serum triglyceride and cholesterol levels of Japanese alcoholic men. PLoS One 10(8):e0133460
Article
PubMed
PubMed Central
Google Scholar
Salameh H, Raff E, Erwin A, Seth D, Nischalke HD, Falleti E, Singal AK (2015) PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease. Am J Gastroenterol 110(6):846–856
Article
CAS
PubMed
Google Scholar
Anstee QM, Seth D, Day CP (2016) Genetic factors that affect risk of alcoholic and nonalcoholic fatty liver disease. Gastroenterology 150(8):1728–1744
Article
PubMed
Google Scholar
He S, McPhaul C, Li JZ, Garuti R, Kinch L, Grishin NV, Hobbs HH (2010) A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 285(9):6706–6715
Article
CAS
PubMed
Google Scholar
Hassan MM, Kaseb A, Etzel CJ, El-Serag H, Spitz MR, Chang P, Li D (2013) Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis prediction. Mol Carcinog 52(S1):139–147
Article
Google Scholar
Burza MA, Molinaro A, Attilia ML, Rotondo C, Attilia F, Ceccanti M, Ginanni Corradini S (2014) PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis. Liver Int 34(4):514–520
Article
CAS
PubMed
Google Scholar
Boccuto L, Abenavoli L (2017) Genetic and epigenetic profile of patients with alcoholic liver disease. Ann Hepatol 16(4):490–500
Article
CAS
PubMed
Google Scholar
Tupala E, Tiihonen J (2004) Dopamine and alcoholism: neurobiological basis of ethanol abuse. Prog Neuro-Psychopharmacol Biol Psychiatry 28(8):1221–1247
Article
CAS
Google Scholar
Hesselbrock V, Higuchi S, Soyka M (2005) Recent developments in the genetics of alcohol-related phenotypes. Alcohol Clin Exp Res 29(7):1321–1324
Article
CAS
PubMed
Google Scholar
Sasabe T, Furukawa A, Matsusita S, Higuchi S, Ishiura S (2007) Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients. Neurosci Lett 412(2):139–142
Article
CAS
PubMed
Google Scholar
Ferguson RA, Goldberg DM (1997) Genetic markers of alcohol abuse. Clin Chim Acta 257(2):199–250
Article
CAS
PubMed
Google Scholar
Goldman D (1995) Candidate genes in alcoholism. Clin Neurosci (New York, NY) 3(3):174–181
CAS
Google Scholar
Arinami T, Gao M, Hamaguchi H, Toru M (1997) A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Hum Mol Genet 6(4):577–582
Article
CAS
PubMed
Google Scholar
Hauge XY, Grandy DK, Eubanks JH, Evans GA, Civelli O, Litt M (1991) Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics 10(3):527–530
Article
CAS
PubMed
Google Scholar
Pohjalainen T, Rinne JO, Någren K, Lehikoinen P, Anttila K, Syvälahti EKG, Hietala J (1998) The A1 allele of the human D 2 dopamine receptor gene predicts low D 2 receptor availability in healthy volunteers. Mol Psychiatry 3(3):256–260
Article
CAS
PubMed
Google Scholar
Laakso A, Pohjalainen T, Bergman J, Kajander J, Haaparanta M, Solin O, Hietala J (2005) The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects. Pharmacogenet Genomics 15(6):387–391
Article
CAS
PubMed
Google Scholar
Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res 348(1):201–203
Article
CAS
PubMed
Google Scholar
Noble EP, Blum K, Ritchie T, Montgomery A, Sheridan PJ (1991) Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism or gene ism. Arch Gen Psychiatry 48(7):648–654
Article
CAS
PubMed
Google Scholar
Ramos-Lopez O, Martinez-Lopez E, Roman S, Fierro NA, Panduro A (2015) Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico. World J Gastroenterol 21(41):11552
Article
CAS
PubMed
PubMed Central
Google Scholar
Kopp M, Morisset R, Rychlik M (2017) Characterization and interrelations of one-carbon metabolites in tissues, erythrocytes, and plasma in mice with dietary-induced folate deficiency. Nutrients 9(5):462
Article
PubMed Central
Google Scholar
Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10(1):111–113
Article
CAS
PubMed
Google Scholar
Bosy-Westphal A, Petersen S, Hinrichsen H, Czech N, Müller MJ (2001) Increased plasma homocysteine in liver cirrhosis. Hepatol Res 20(1):28–38
Article
CAS
PubMed
Google Scholar
Ventura P, Rosa MC, Abbati G, Marchini S, Grandone E, Vergura P, Zeneroli ML (2005) Hyperhomocysteinaemia in chronic liver diseases: role of disease stage, vitamin status and methylenetetrahydrofolate reductase genetics. Liver Int 25(1):49–56
Article
CAS
PubMed
Google Scholar
Toniutto P, Fabris C, Falleti E, Cussigh A, Fontanini E, Bitetto D, Pirisi M (2008) Methylenetetrahydrofolate reductase C677T polymorphism and liver fibrosis progression in patients with recurrent hepatitis C. Liver Int 28(2):257–263
Article
CAS
PubMed
Google Scholar
Adinolfi LE, Ingrosso D, Cesaro G, Cimmino A, D'Antò M, Capasso R, Ruggiero G (2005) Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology 41(5):995–1003
Article
CAS
PubMed
Google Scholar
Dawood RM, Mahmoud EM, Ibrahim MK, Din NG, Aboul-Enein A, Zayed N, Awady MK (2017) Methylenetetrahydrofolate reductase gene polymorphism is associated with severity of liver steatosis in chronically infected patients with HCV genotype 4. Clin Lab 63:419–426
Article
CAS
PubMed
Google Scholar
Fernández-Miranda C, Manzano ML, Fernández I, López-Alonso G, Gómez P, Ayala R, Castellano G (2011) Asociación entre hiperhomocisteinemia y esteatosis hepática en pacientes con hepatitis crónica C. Med Clin (Barc) 136(2):45–49
Article
Google Scholar
Petta S, Bellia C, Mazzola A, Cabibi D, Camma C, Caruso A, Ciaccio M (2012) Methylenetetrahydrofolate reductase homozygosis and low-density lipoproteins in patients with genotype 1 chronic hepatitis C. J Viral Hepat 19(7):465–472
Article
CAS
PubMed
Google Scholar
Samokhodskaya LM, Starostina EE, Sulimov AV, Krasnova TN, Rosina TP, Avdeev VG, Sadovnichii VA (2019) Prediction of features of the course of chronic hepatitis C using Bayesian networks. Ter Arkh 91(2):32–39
CAS
PubMed
Google Scholar
Weisberg I, Tran P, Christensen B, Sibani S, Rozen R (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64(3):169–172
Article
CAS
PubMed
Google Scholar
Luo Z, Lu Z, Muhammad I, Chen Y, Chen Q, Zhang J, Song Y (2018) Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis. Lipids Health Dis 17(1):1–15
Google Scholar
Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP (2004) Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 126(2):586–597
Article
CAS
PubMed
Google Scholar
Fabris C, Toniutto P, Falleti E, Fontanini E, Cussigh A, Bitetto D, Pirisi M (2009) MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption. Alcohol Clin Exp Res 33(1):102–107
Article
CAS
PubMed
Google Scholar
Avila MA, Berasain C, Torres L, Martin-Duce A, Corrales FJ, Yang H, Mato JM (2000) Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol 33(6):907–914
Article
CAS
PubMed
Google Scholar
Peres NP, Galbiatti-Dias ALS, Castanhole-Nunes MMU, da Silva RF, Pavarino ÉC, Goloni-Bertollo EM, Ruiz-Cintra MT (2016) Polymorphisms of folate metabolism genes in patients with cirrhosis and hepatocellular carcinoma. World J Hepatol 8(29):1234
Article
PubMed
PubMed Central
Google Scholar
Locke WJ, Clark SJ (2012) Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis. Breast Cancer Res 14(6):1–14
Article
Google Scholar
Fan M, Yan PS, Hartman-Frey C, Chen L, Paik H, Oyer SL, Nephew KP (2006) Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogen’s tamoxifen and fulvestrant. Cancer Res 66(24):11954–11966
Article
CAS
PubMed
Google Scholar
Zakhari S, Hoek JB (2015) Alcohol and breast cancer: reconciling epidemiological and molecular data. Biological basis of alcohol-induced cancer. Adv Exp Med Biol 815:7–39
Carim-Todd L, Escarceller M, Estivill X, Sumoy L (2000) Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24→ q26 and 19p13. 3→ p12. Cytogenet Cell Genet 90(3-4):255–260
Article
CAS
PubMed
Google Scholar
Mahdessian H, Taxiarchis A, Popov S, Silveira A, Franco-Cereceda A, Hamsten A, can’t Hooft F (2014) TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. Proc Natl Acad Sci U S A 111(24):8913–8918
Article
CAS
PubMed
PubMed Central
Google Scholar
Du S, Lu L, Miao Y, Jin W, Li C, Xin Y, Xuan S (2017) E167K polymorphism of TM6SF2 gene affects cell cycle of hepatocellular carcinoma cell HEPA 1-6. Lipids Health Dis 16(1):1–5
Article
CAS
Google Scholar
Kahali B, Liu YL, Daly AK, Day CP, Anstee QM, Speliotes EK (2015) TM6SF2: catch-22 in the fight against nonalcoholic fatty liver disease and cardiovascular disease? Gastroenterology 148(4):679–684
Article
PubMed
Google Scholar
Liu YL, Reeves HL, Burt AD, Tiniakos D, McPherson S, Leathart JB, Anstee QM (2014) TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with nonalcoholic fatty liver disease. Nat Commun 5(1):1–6
Google Scholar
Garlanda C, Dinarello CA, Mantovani A (2013) The interleukin-1 family: back to the future. Immunity 39(6):1003–1018
Article
CAS
PubMed
PubMed Central
Google Scholar
Hurme M, Santtila S (1998) IL-1 receptor antagonist (IL-1Ra) plasma levels are coordinately regulated by both IL-1Ra and IL-1β genes. Eur J Immunol 28(8):2598–2602
Article
CAS
PubMed
Google Scholar
Mandrekar P, Szabo G (2009) Signaling pathways in alcohol-induced liver inflammation. J Hepatol 50(6):1258–1266
Article
CAS
PubMed
PubMed Central
Google Scholar
Zeng T, Xie KQ (2009) Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. Arch Toxicol 83(12):1075–1081
Article
CAS
PubMed
Google Scholar
Sánchez-Catalán MJ, Hipólito L, Guerri C, Granero L, Polache A (2008) Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat. Alcohol Alcohol 43(4):401–407
Article
PubMed
Google Scholar
Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ (2012) Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-α, and CYP2E1. Food Chem Toxicol 50(3-4):485–491
Article
CAS
PubMed
Google Scholar
Lu Y, Zhuge J, Wang X, Bai J, Cederbaum AI (2008) Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 47(5):1483–1494
Article
CAS
PubMed
Google Scholar
Lu Y, Cederbaum AI (2008) CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 44(5):723–738
Article
CAS
PubMed
Google Scholar
Hayashi SI, Watanabe J, Kawajiri K (1991) Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P45011E1 gene. J Biochem 110(4):559–565
Article
CAS
PubMed
Google Scholar
Parsian A, Cloninger CR, Zhang ZH (1998) Association studies of polymorphisms of CYP2E1 gene in alcoholics with cirrhosis, antisocial personality, and normal controls. Alcohol Clin Exp Res 22(4):888–891
Article
CAS
PubMed
Google Scholar