Fig. 9
From: The role of genetic mutation in alcoholic liver disease
Effect of alcohol on homocysteine/methionine metabolism and DNA methylation. In addition, alcohol disrupts the folate cycle involved in methionine metabolism, which is crucial to providing the methyl groups required for methylation of DNA. Folate is an essential nutrient for the production of DNA and a complicated folate cycle, including methylenetetrahydrofolate reductase (MTHFR)