Buonfiglioli F, AP CF, Crespi C, Foschi FG, Lenzi M et al (2016) Development of hepatocellular carcinoma in HCV cirrhotic patients treated with direct acting antivirals. Annual Meeting of EASL, Barcelona
Book
Google Scholar
Elgharably A, Gomaa AI, Crossey MM, Norsworthy PJ, Waked I, Taylor-Robinson SD (2017) Hepatitis C in Egypt - past, present, and future. Int J Gen Med 10:1–6. https://doi.org/10.2147/IJGM.S119301
Article
PubMed
Google Scholar
Messina JP, Humphreys I, Flaxman A, Brown A, Cooke GS, Pybus OG, Barnes E (2015) Global distribution and prevalence of hepatitis C virus genotypes. Hepatology. 61(1):77–87. https://doi.org/10.1002/hep.27259
Article
PubMed
Google Scholar
Kouyoumjian SP, Chemaitelly H, Abu-Raddad LJ (2018) Characterizing hepatitis C virus epidemiology in Egypt: systematic reviews, meta-analyses, and meta-regressions. Sci Rep 8(1):1661. https://doi.org/10.1038/s41598-017-17936-4
Article
CAS
PubMed
PubMed Central
Google Scholar
Li K, Lemon SM (2013) Innate immune responses in hepatitis C virus infection. Semin Immunopathol 35(1):53–72. https://doi.org/10.1007/s00281-012-0332-x
Article
CAS
PubMed
Google Scholar
Zekri A-RN, Ashour MSE-D, Hassan A, Alam El-Din HM, El-Shehaby AMR, Abu-Shady MA (2005) Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression. World J Gastroenterol 11(42):6624–6630. https://doi.org/10.3748/wjg.v11.i42.6624
Article
PubMed
PubMed Central
Google Scholar
Bruno CM, Valenti M, Bertino G, Ardiri A, Amoroso A, Consolo M, Mazzarino CM, Neri S (2011) Relationship between circulating interleukin-10 and histological features in patients with chronic C hepatitis. Ann Saudi Med 31(4):360–364. https://doi.org/10.4103/0256-4947.83215
Article
PubMed
PubMed Central
Google Scholar
Wilson EB, Brooks DG (2011) The role of IL-10 in regulating immunity to persistent viral infections. Curr Top Microbiol Immunol 350:39–65. https://doi.org/10.1007/82_2010_96
Article
CAS
PubMed
PubMed Central
Google Scholar
El-Emshaty HM, Nasif WA, Mohamed IE (2015) Serum cytokine of IL-10 and IL-12 in chronic liver disease: the immune and inflammatory response. Dis Markers 2015:707254
Article
PubMed
PubMed Central
Google Scholar
Ejrnaes M, Filippi CM, Martinic MM, Ling EM, Togher LM, Crotty S, von Herrath MG (2006) Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med 203(11):2461–2472. https://doi.org/10.1084/jem.20061462
Article
CAS
PubMed
PubMed Central
Google Scholar
Taktak-BenAmar A, Morjen M, Ben Mabrouk H, Abdelmaksoud-Dammak R, Guerfali M, Fourati-Masmoudi N et al (2017) Expression, purification and functionality of bioactive recombinant human vascular endothelial growth factor VEGF(165) in E. coli. AMB Express 7(1):33
Article
PubMed
PubMed Central
Google Scholar
Koch S, Claesson-Welsh L (2012) Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2(7):a006502. https://doi.org/10.1101/cshperspect.a006502
Article
CAS
PubMed
PubMed Central
Google Scholar
Mee CJ, Harris HJ, Farquhar MJ, Wilson G, Reynolds G, Davis C, van IJzendoorn SCD, Balfe P, McKeating JA (2009) Polarization restricts hepatitis C virus entry into HepG2 hepatoma cells. J Virol 83(12):6211–6221. https://doi.org/10.1128/JVI.00246-09
Article
CAS
PubMed
PubMed Central
Google Scholar
Llovet JM, Pena CE, Lathia CD, Shan M, Meinhardt G, Bruix J (2012) Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma. Clin Cancer Res 18(8):2290–2300. https://doi.org/10.1158/1078-0432.CCR-11-2175
Article
CAS
PubMed
Google Scholar
Hepatitis C (2018) Guidance 2018 update: AASLD-IDSA recommendations for testing, managing, and treating hepatitis C virus infection. Clin Infect Dis 67(10):1477–1492
Article
Google Scholar
WHO (2016) WHO guidelines for the screening care and treatment of persons with chronic hepatitis C infection. World Health Organization, Geneva, pp 25–26
Google Scholar
Doumas BT, Watson WA, Biggs HG (1971) Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta 31(1):87–96. https://doi.org/10.1016/0009-8981(71)90365-2
Article
CAS
PubMed
Google Scholar
Jendrassik LGP (1938) Vereinfachte photometrische Methode zur Bestimmung des Bilirubins. Biochem Z 297:81–89
CAS
Google Scholar
Bergmeyer HU, Horder M, Rej R (1986) International Federation of Clinical Chemistry (IFCC) scientific committee, analytical section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC method for alanine aminotransferase (L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2). J Clin Chem Clin Biochem 24(7):481–495
CAS
PubMed
Google Scholar
Rej R (1984) Measurement of aminotransferases: part 1. Aspartate aminotransferase. Crit Rev Clin Lab Sci 21(2):99–186. https://doi.org/10.3109/10408368409167137
Article
CAS
PubMed
Google Scholar
Lewis SMBB, Bates I (2017) Chapter 16:investigation of haemostsis (CBC, PT, INR). In: Dacie and Lewis practical Haematology, 12th edn. J and Churchil Elsevier Ltd, Philadelphia, pp 389–391
Google Scholar
Halfon P, Bourlière M, Pénaranda G, Khiri H, Ouzan D (2006) Real-time PCR assays for hepatitis C virus (HCV) RNA quantitation are adequate for clinical management of patients with chronic HCV infection. J Clin Microbiol 44(7):2507–2511. https://doi.org/10.1128/JCM.00163-06
Article
CAS
PubMed
PubMed Central
Google Scholar
Kuang J, Yan X, Genders AJ, Granata C, Bishop DJ (2018) An overview of technical considerations when using quantitative real-time PCR analysis of gene expression in human exercise research. PLoS One 13(5):e0196438 Available from: http://europepmc.org/abstract/MED/29746477. https://doi.org/10.1371/journal.pone.0196438, http://europepmc.org/articles/PMC5944930http://europepmc.org/articles/PMC5944930?pdf=render
Article
PubMed
PubMed Central
Google Scholar
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25(4):402–408. https://doi.org/10.1006/meth.2001.1262
Article
CAS
PubMed
Google Scholar
WHO (2018) Guidelines for the Care and Treatment of Persons Diagnosed with Chronic Hepatitis C Virus Infection [Internet] Geneva: WHO
Horsley-Silva JL, Vargas HE (2017) New therapies for Hepatitis C virus infection. Gastroenterol Hepatol (N Y) 13(1):22–31
Google Scholar
El Raziky MGM, Hammad R (2015) Treatment of hepatitis C genotype 4 patients with simeprevir and sofosbuvir: preliminary results from a phase IIa, partially randomised, open-label trial conducted in Egypt (OSIRIS). Hepatology 62(1):145A
Google Scholar
Lawitz E, Poordad F, Brainard DM, Hyland RH, An D, Dvory-Sobol H, Symonds WT, McHutchison JG, Membreno FE (2015) Sofosbuvir with peginterferon-ribavirin for 12 weeks in previously treated patients with hepatitis C genotype 2 or 3 and cirrhosis. Hepatology. 61(3):769–775. https://doi.org/10.1002/hep.27567
Article
CAS
PubMed
Google Scholar
Feld JJ, Jacobson IM, Hezode C, Asselah T, Ruane PJ, Gruener N et al (2015) Sofosbuvir and Velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection. N Engl J Med 373(27):2599–2607. https://doi.org/10.1056/NEJMoa1512610
Article
CAS
PubMed
Google Scholar
Gayam V, Khalid M, Mandal AK, Hussain MR, Mukhtar O, Gill A, Garlapati P, Shrestha B, Guss D, Sherigar J, Mansour M, Mohanty S (2018) Direct-acting antivirals in chronic hepatitis c genotype 4 infection in community care setting. Gastroenterology Res 11(2):130–137. https://doi.org/10.14740/gr999w
Article
CAS
PubMed
PubMed Central
Google Scholar
Chatterjee M, Anju CP, Biswas L, Anil Kumar V, Gopi Mohan C, Biswas R (2016) Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options. Int J Med Microbiol 306(1):48–58. https://doi.org/10.1016/j.ijmm.2015.11.004
Article
CAS
PubMed
Google Scholar
Huynh T, Zhang J, Hu KQ (2018) Hepatitis C virus clearance by direct-acting antiviral results in rapid resolution of hepatocytic injury as indicated by both alanine aminotransferase and aspartate aminotransferase normalization. J Clin Transl Hepatol 6(3):258–263. https://doi.org/10.14218/JCTH.2018.00014
Article
PubMed
PubMed Central
Google Scholar
Khan ST, McGuinty M, Corsi DJ, Cooper CL (2017) Liver enzyme normalization predicts success of Hepatitis C oral direct-acting antiviral treatment. Clin Invest Med 40(2):E73–e80
Article
CAS
PubMed
Google Scholar
Yen Y-H KF-Y, Kee K-M, Chang K-C, Tsai M-C, Hu T-H et al (2018) APRI and FIB-4 in the evaluation of liver fibrosis in chronic hepatitis C patients stratified by AST level. PLoS One 13(6):e0199760. https://doi.org/10.1371/journal.pone.0199760
Article
CAS
PubMed
PubMed Central
Google Scholar
Bachofner JA, Valli PV, Kroger A, Bergamin I, Kunzler P, Baserga A et al (2017) Direct antiviral agent treatment of chronic hepatitis C results in rapid regression of transient elastography and fibrosis markers fibrosis-4 score and aspartate aminotransferase-platelet ratio index. Liver Int 37(3):369–376. https://doi.org/10.1111/liv.13256
Article
CAS
PubMed
Google Scholar
Hengst J, Falk CS, Schlaphoff V, Deterding K, Manns MP, Cornberg M, Wedemeyer H (2016) Direct-acting antiviral-induced hepatitis c virus clearance does not completely restore the altered cytokine and chemokine milieu in patients with chronic hepatitis C. J Infect Dis 214(12):1965–1974. https://doi.org/10.1093/infdis/jiw457
Article
CAS
PubMed
Google Scholar
Meissner EG, Lee YJ, Osinusi A, Sims Z, Qin J, Sturdevant D, McHutchison J, Subramanian M, Sampson M, Naggie S, Patel K, Remaley AT, Masur H, Kottilil S (2015) Effect of sofosbuvir and ribavirin treatment on peripheral and hepatic lipid metabolism in chronic hepatitis C virus, genotype 1-infected patients. Hepatology. 61(3):790–801. https://doi.org/10.1002/hep.27424
Article
CAS
PubMed
Google Scholar
Othman MS, Aref AM, Mohamed AA, Ibrahim WA (2013) Serum levels of interleukin-6 and interleukin-10 as biomarkers for hepatocellular carcinoma in Egyptian patients. ISRN Hepatol 2013:412317
Article
PubMed
PubMed Central
Google Scholar
Yoneda S, Umemura T, Katsuyama Y, Kamijo A, Joshita S, Komatsu M, Ichijo T, Matsumoto A, Yoshizawa K, Ota M, Tanaka E, the Nagano Interferon Treatment Research Group (2011) Association of serum cytokine levels with treatment response to pegylated interferon and ribavirin therapy in genotype 1 chronic hepatitis C patients. J Infect Dis 203(8):1087–1095. https://doi.org/10.1093/infdis/jiq165
Article
CAS
PubMed
Google Scholar
Saraiva GN, do Rosario NF, Medeiros T, Leite PEC, Lacerda GS, de Andrade TG et al (2018) Restoring inflammatory mediator balance after Sofosbuvir-induced viral clearance in patients with chronic Hepatitis C. Mediat Inflamm 2018:8578051
Article
Google Scholar
Villani R, Facciorusso A, Bellanti F, Tamborra R, Piscazzi A, Landriscina M, Vendemiale G, Serviddio G (2016) DAAs rapidly reduce inflammation but increase serum VEGF level: a rationale for tumor risk during anti-HCV treatment. PLoS One 11(12):e0167934. https://doi.org/10.1371/journal.pone.0167934
Article
CAS
PubMed
PubMed Central
Google Scholar
Alhetheel A, Albarrag A, Shakoor Z, Alswat K, Abdo A, Al-Hamoudi W (2016) Assessment of pro-inflammatory cytokines in sera of patients with hepatitis C virus infection before and after anti-viral therapy. J Infect Dev Ctries 10(10):1093–1098. https://doi.org/10.3855/jidc.7595
Article
CAS
PubMed
Google Scholar
Carlin AF, Aristizabal P, Song Q, Wang H, Paulson MS, Stamm LM, Schooley RT, Wyles DL (2015) Temporal dynamics of inflammatory cytokines/chemokines during sofosbuvir and ribavirin therapy for genotype 2 and 3 hepatitis C infection. Hepatology. 62(4):1047–1058. https://doi.org/10.1002/hep.27971
Article
CAS
PubMed
Google Scholar
Debes JD, van Tilborg M, Groothuismink ZMA, Hansen BE, Schulze Zur Wiesch J, von Felden J et al (2018) Levels of cytokines in serum associate with development of hepatocellular carcinoma in patients with HCV infection treated with direct-acting antivirals. Gastroenterology 154(3):515–7.e3
Article
CAS
PubMed
Google Scholar
Kawaguchi T, Ide T, Koga H, Kondo R, Miyajima I, Arinaga-Hino T, Kuwahara R, Amano K, Niizeki T, Nakano M, Kuromatsu R, Torimura T (2018) Rapidly growing hepatocellular carcinoma after direct-acting antiviral treatment of chronic hepatitis C. Clin J Gastroenterol 11(1):69–74. https://doi.org/10.1007/s12328-017-0789-1
Article
PubMed
Google Scholar
Serti E, Chepa-Lotrea X, Kim YJ, Keane M, Fryzek N, Liang TJ et al (2015) Successful interferon-free therapy of chronic hepatitis C virus infection normalizes natural killer cell function. Gastroenterology 149(1):190–200.e2
Article
CAS
PubMed
Google Scholar
Faillaci F, Marzi L, Critelli R, Milosa F, Schepis F, Turola E, Andreani S, Vandelli G, Bernabucci V, Lei B, D'Ambrosio F, Bristot L, Cavalletto L, Chemello L, Sighinolfi P, Manni P, Maiorana A, Caporali C, Bianchini M, Marsico M, Turco L, de Maria N, del Buono M, Todesca P, di Lena L, Romagnoli D, Magistri P, di Benedetto F, Bruno S, Taliani G, Giannelli G, Martinez-Chantar ML, Villa E (2018) Liver angiopoietin-2 is a key predictor of de novo or recurrent hepatocellular cancer after hepatitis C virus direct-acting antivirals. Hepatology. 68(3):1010–1024. https://doi.org/10.1002/hep.29911
Article
CAS
PubMed
Google Scholar
Park MS, Kim S, Patel J, Hajdu CH, Do RK, Mannelli L et al (2012) Hepatocellular carcinoma: detection with diffusion-weighted versus contrast-enhanced magnetic resonance imaging in pretransplant patients. Hepatology. 56(1):140–148. https://doi.org/10.1002/hep.25681
Article
PubMed
Google Scholar