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Egyptian Liver Journal

Table 7 Agreement (sensitivity, specificity) for ATG5, BECLIN1 and AFP to diagnose HCC patients from Cirrhotic

From: Serum Beclin 1 and autophagy-related protein-5 and the risk of hepatocellular carcinoma among cirrhotic hepatitis C patients

  AUC p 95% C. I Cut off# Sensitivity Specificity PPV NPV Accuracy
LL UL
ATG5(ng/ml) 0.670 0.024* 0.534 0.806  ≤ 95.7 76.67 53.33 62.2 69.6 65.0
BECLIN1(ng/ml) 0.824  < 0.001* 0.715 0.933  > 5.3 93.33 66.67 73.7 90.9 80.0
AFP(ng/ml) 0.659 0.034* 0.521 0.798  > 70 26.7 83.3 61.5 54.2 49.3
p value for comparative ATG5 vs. BECLIN1 Z = 1.623, p = 0.105
ATG5 vs. AFP Z = 0.104, p = 0.917
BECLIN1 vs. AFP Z = 1.830, p = 0.067
  1. AUC: Area Under a Curve; p value: Probability value
  2. CI: Confidence Intervals
  3. NPV: Negative predictive value; PPV: Positive predictive value
  4. *: Statistically significant at p ≤ 0.05
  5. #Cut off was choose according to Youden index
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