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Table 7 Agreement (sensitivity, specificity) for ATG5, BECLIN1 and AFP to diagnose HCC patients from Cirrhotic

From: Serum Beclin 1 and autophagy-related protein-5 and the risk of hepatocellular carcinoma among cirrhotic hepatitis C patients

 

AUC

p

95% C. I

Cut off#

Sensitivity

Specificity

PPV

NPV

Accuracy

LL

UL

ATG5(ng/ml)

0.670

0.024*

0.534

0.806

 ≤ 95.7

76.67

53.33

62.2

69.6

65.0

BECLIN1(ng/ml)

0.824

 < 0.001*

0.715

0.933

 > 5.3

93.33

66.67

73.7

90.9

80.0

AFP(ng/ml)

0.659

0.034*

0.521

0.798

 > 70

26.7

83.3

61.5

54.2

49.3

p value for comparative

ATG5 vs. BECLIN1 Z = 1.623, p = 0.105

ATG5 vs. AFP Z = 0.104, p = 0.917

BECLIN1 vs. AFP Z = 1.830, p = 0.067

  1. AUC: Area Under a Curve; p value: Probability value
  2. CI: Confidence Intervals
  3. NPV: Negative predictive value; PPV: Positive predictive value
  4. *: Statistically significant at p ≤ 0.05
  5. #Cut off was choose according to Youden index