Tissue inhibitor of matrix metalloprotinase-1 and collagen type IV in HCV-associated cirrhosis and grading of esophageal varices

Egyptian Liver Journal

Table 5 Comparison between the different studied groups according to collagen type IV and TIMP

	Group 1 (n = 30)	Group 2 (n = 60)			Control (n = 30)	H p
	Group 1 (n = 30)	Grade I (n = 17)	Grade II (n = 22)	Grade III (n = 21)	Control (n = 30)	H p
Collagen type IV (pg/ml)
Min.–Max.	522.0–858.0	580.0–907.0	921.0–1107.0	1118.0–2901.0	200.0–1426.0	H = 93.318^* p < 0.001^*
Mean ± SD.	729.1 ± 80.29	768.6 ± 137.9	1018.8 ± 57.36	1770.7 ± 663.4	447.8 ± 283.2
Median	744.5	876.0	1023.5	1486.0	342.0
IQR	694.0–772.0	627.0–896.0	963.0–1064.0	1251.0–2470.0	250.0–570.0
p₀	0.004^*	0.005^*	< 0.001^*	< 0.001^*
p₁		0.693	< 0.001^*	< 0.001^*
Sig. bet. grps		p₂ = 0.003^, p₃ < 0.001^, p₄ = 0.032^*
TIMP (μg/L)
Min. –Max.	6.0–46.0	6.0–108.0	7.0–108.0	9.0–108.0	5.0–69.0	H = 44.366^* p < 0.001^*
Mean ± SD.	24.87 ± 12.53	32.88 ± 25.97	41.86 ± 26.47	55.14 ± 38.64	12.50 ± 11.59
Median	23.0	23.0	36.0	38.0	11.0
IQR	16.0–36.0	20.0–32.0	22.0–47.0	22.0–90.0	5.0–13.0
p₀	< 0.001^*	< 0.001^*	< 0.001^*	< 0.001^*
p₁		0.584	0.044^*	0.025^*
Sig. bet. grps		p₂ = 0.216, p₃ = 0.150, p₄ = 0.819

IQR interquartile range, SD standard deviation, H H for Kruskal-Wallis test, pairwise comparison bet. each 2 groups was done using Post Hoc Test (Dunn’s for multiple comparisons test)
p: p value for comparing between the different studied groups
p0: p value for comparing between Control and each other group
p1: p value for comparing between group 1 and each other group
p2: p value for comparing between group 2 (grade I) and group 2 (grade II)
p3: p value for comparing between group 2 (grade I) and group 2 (grade III)
p4: p value for comparing between group 2 (grade II) and group 2 (grade III)
* Statistically significant at p ≤ 0.05