Tissue inhibitor of matrix metalloprotinase-1 and collagen type IV in HCV-associated cirrhosis and grading of esophageal varices

Egyptian Liver Journal

Table 3 Comparison between the three studied groups according to physical examination

	Group 1 (n = 30)		Group 2 (n = 60)		Control (n = 30)		Test of Sig.	P
	No.	%	No.	%	No.	%	Test of Sig.	P
Ascites	0	0.0	50	83.3	0	0.0	χ² = 85.71^*	< 0.001^*
Mild	–	–	9	18.0	–	–
Moderate	–	–	28	56.0	–	–	–	–
Severe	–	–	13	26.0	–	–
Splenomegaly	30	100.0	55	91.7	0	0.0	χ² = 2.647	^FEp = 0.165
Spleen length
Min. –Max.	14.0–17.0		15.0–20.0		10.0–12.0		F = 402.74^*	< 0.001^*
Mean ± SD.	15.60 ± 0.67		17.52 ± 1.19		11.43 ± 0.63
Median (IQR)	16.0 (15.0–16.0)		17.0 (17.0–18.50)		11.50 (11.0–12.0)
Sig. bet. grps.	p₁ < 0.001^, p₂ < 0.001^, p₃ < 0.001^*
Portal vein diameter
Min. –Max.	14.50–15.50		15.50–19.50		8.0–12.0		F = 581.23^*	< 0.001^*
Mean ± SD.	14.77 ± 0.45		17.38 ± 1.10		9.63 ± 1.22
Median (IQR)	14.50(14.5–15.5)		17.50(16.5–18.5)		9.50 (9.0–11.0)
Sig. bet. grps.	p₁ < 0.001^, p₂ < 0.001^, p₃ < 0.001^*
Hepatic encephalopathy
No	27	90.0	3	5.0	–	–	χ² = 65.025^*	< 0.001^*
Grade 1	3	10.0	57	95.0	–	–
Grade 2	0	0.0	0	0.0	–	–
Grade 3	0	0.0	0	0.0	–	–
Grade 4	0	0.0	0	0.0	–	–

χ² Chi square test, IQR interquartile range, SD standard deviation, F F for one-way ANOVA test, pairwise comparison bet. each 2 groups was done using Post Hoc Test (Tukey)
p: p value for comparing between the three studied groups
p1: p value for comparing between group 1 and group 2
p2: p value for comparing between group 1 and control
p3: p value for comparing between group 2 and control
* Statistically significant at p ≤ 0.05