The value of simultaneous determination of blood large neutral amino acids and tetrahydrobiopterin metabolites in the diagnosis of atypical hyperphenylalaninemia

Egyptian Liver Journal

Table 5 The sensitivity and specificity of neopterin and biopterin in the classification of PKU into typical and atypical cases

PKU phenylketonuria, Phe phenylalanine, BH4 tetrahydrobiopterin, Sen sensitivity, Spe specificity
Sensitivity (%) = (TP/TP + FN) × 100; specificity (%) = (TN/TN + FP) × 100
^aTP = true positive
^bFP = false positive
^cFN = false negative
^dTN = true negative