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Egyptian Liver Journal

Table 4 Correlation between biopterin, neopterin, and Phe in the studied groups

From: The value of simultaneous determination of blood large neutral amino acids and tetrahydrobiopterin metabolites in the diagnosis of atypical hyperphenylalaninemia

 

Neopterin (nm/L)

Biopterin (nm/L)

Classic PKU, n = 46

Atypical PKU, n = 14

Control, n = 50

Classic PKU, n = 46

Atypical PKU, n = 14

Control, n = 50

Cor. = r Sig = p

r

p

r

p

r

p

r

p

r

p

r

p

Phe (μm/L)

0.62**

< 0.01

0.39

0.25

0.28*

0.05

0.64**

< 0.01

0.23

0.421

0.22

0.13

Tyr (μm/L)

0.21

0.15

− 0.73**

< 0.01

0.22

0.13

0.18

0.24

− 0.71**

< 0.01

0.20

0.16

P/T ratio

0.49**

< 0.01

0.76**

< 0.01

− 0.08

0.56

0.56**

< 0.01

0.68**

< 0.01

− 0.16

0.28

Biopterin

0.84**

< 0.01

0.88**

< 0.01

0.90**

< 0.01

      
  1. PKU phenylketonuria, Phe phenylalanine, Tyr tyrosine, PT phenylalnine to tyrosine ratio, r Spearman coefficient
  2. *P-value < 0.01 indicates a highly significant correlation
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