Diagnostic and prognostic significance of tissue lncRNA HOTAIR and hexokinase 2 mRNA expression in patients with pancreatic ductal adenocarcinoma

Egyptian Liver Journal

Table 5 Survival analysis: cox regression of demographic and clinicopathological factors in PDAC patients

	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age > 60	0.7 (0.2–2.1)	0.6
Gender	0.5 (0.19–1.7)	0.3
Tumor size ≥ 4	0.5 (0.18–1.7)	0.3
LVI	1.7 (0.5–5.03)	0.3
TNM classification
N1	1.3 (0.2–7.5)	0.7
N2	1.05 (0.2–5.3)	0.9
Pathological stage	0.4 (0.14–1.25)	0.12	3.4 (1.009–11.62)	0.04
HK2 high expression (above median)	3.7 (1.24–11.4)	0.01	4.8 (1.4–16.59)	0.01
lncRNA HOTAIR high expression (above median)	4.5 (1.04–19.5)	0.04	4.08 (0.8–19.35)	0.07

Statistical analysis of demographic data and clinicopathological features: Univariable and Multivariable Cox regression results. CI confidence interval, HR hazard ratio, significance level at P value < 0.05, LVI lymph vascular invasion, HK2 hexokinase 2, lncRNA HOTAIR HOX transcript antisense RNA, TNM classification N1 indicates 1 to 3 lymph nodes with cancer cells, N2 indicates cancer in 4 or more lymph nodes