Egyptian Liver Journal

Table 9 Hepcidin and serum AFP’s diagnostic performance in distinguishing group II (patients with cirrhosis and HCC) (n = 30) from group I (patients with cirrhosis and no HCC) (n = 30)

From: Serum level of hepcidin in cirrhotic patients as a marker for hepatocellular carcinoma

	AUC	p	95% CI	Cutoff	Sensitivity	Specificity	PPV	NPV
Hepcidin (ng/ml)	0.721	0.003*	0.581–0.861	≤ 1.1164#	73.33	76.67	75.9	74.2
Serum AFP (ng/ml)	0.882	< 0.001*	0.793–0.972	> 12	73.33	80.0	78.6	75.0
Combination	0.881	< 0.001*	0.791 0.972		73.33	100.0	100.0	78.95

AUC Area under a curve. p-value probability value. CI Confidence intervals. NPV Negative predictive value. PPV Positive predictive value. *Statistically significant at p ≤ 0.05. #Cutoff was chosen according to Youden index

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