Table 3 Distribution of genotype and allele frequencies and association of single SNPs within the BDNF gene with liver cirrhosis in heavy drinkers

rs925946

GG, n (%)

GT, n (%)

TT, n (%)

Dominant model

GG, n (%)

GT+TT, n (%)

Recessive model

GG+GT, n (%)

TT, n (%)

G allele, n (%)

T allele, n (%)

45 (63.4)

24 (33.8)

2 (2.8)

45 (63.4)

26 (36.6)

69 (97.2)

2 (2.8)

114 (80.3)

28 (19.7)

62 (56.4)

36 (32.7)

12 (10.9)

62 (56.4)

48 (43.6)

98 (89.1)

12 (10.9)

160 (72.7)

60 (27.3)

0.009 (0.924)

2.935 (0.087)

0.613 (0.434)

2.907 (0.088)

2.282 (0.131)

1

0.984 (0.480–2.019), 0.966

6.287 (1.286–30.738), 0.023

1

1.366 (0.700–2.665), 0.360

1

6.321 (1.317–30.348), 0.021

rs6265

GG, n (%)

GA, n (%)

AA, n (%)

Dominant model

GG, n (%)

GA+AA, n (%)

Recessive model

GG+GA

AA, n (%)

G allele, n (%)

A allele, n (%)

52 (73.2)

16 (22.5)

3 (4.2)

52 (73.2)

19 (26.8)

68 (95.8)

3 (4.2)

120 (84.5)

22 (15.5)

80 (72.7)

29 (26.4)

1 (0.9)

80 (72.7)

30 (27.3)

109 (99.1)

1 (0.9)

189 (85.9)

31 (14.1)

0.078 (0.780)

0.833 (0.361)

0.009 (0.924)

0.929 (0.335)

0.047 (0.829)

1

0.182 (0.014–2.354), 0.192

0.947 (0.435–2.063), 0.891

1

0.828 (0.392–1.750), 0.620

1

0.184 (0.014–2.365), 0.194

rs10835210

CC, n (%)

CA, n (%)

AA, n (%)

Dominant model

CC, n (%)

CA+AA, n (%)

Recessive model

CC+CA

AA, n (%)

C allele, n (%)

A allele, n (%)

12 (16.9)

33 (46.5)

26 (36.6)

12 (16.9)

59 (83.1)

45 (63.4)

26 (36.6)

57 (40.1)

85 (59.9)

29 (26.4)

48 (43.6)

33 (30.0)

29 (26.4)

81 (73.6)

77 (70.0)

33 (30.0)

106 (48.2)

114 (51.8)

1.086 (0.297)

1.665 (0.197)

1.698 (0.193)

0.586 (0.444)

1.941 (0.164)

10.595 (0.249–1.421), 0.243

0.570 (0.202–1.269), 0.147

1

0.556 (0.247–1.251), 0.156

1

0.721 (0.360–1.442), 0.355

rs7103411

TT, n (%)

TC, n (%)

CC, n (%)

Dominant model

TT, n (%)

TC+CC, n (%)

Recessive model

TT+TC

CC, n (%)

T allele, n (%)

C allele, n (%)

49 (69.0)

22 (31.0)

0 (0.0)

49 (69.0)

22 (31.0)

71 (100.0)

0 (0.0)

120 (84.5)

22 (15.5)

75 (68.2)

35 (31.8)

0 (0.0)

75 (68.2)

35 (31.8)

110 (100.0)

0 (0.0)

185 (84.1)

35 (15.9)

0.002 (0.963)

–––

0.002 (0.963)

–––

0.002 (0.967)

1

0.892 (0.439–1.814), 0.752

–––

1

0.892 (0.439–1.814), 0.752

–––

rs75945125

TT, n (%)

TC, n (%)

CC, n (%)

Dominant model

TT, n (%)

TC+CC, n (%)

Recessive model

TT+TC

CC, n (%)

T allele, n (%)

C allele, n (%)

65 (91.5)

6 (8.5)

0 (0.0)

65 (91.5)

6 (8.5)

71 (100.0)

0 (0.0)

136 (95.8)

6 (4.2)

98 (89.1)

12 (10.9)

0 (0.0)

98 (89.1)

12 (10.9)

110 (100.0)

0 (0.0)

208 (94.5)

12 (5.5)

0.081 (0.775)

–––

0.081 (0.775)

–––

0.077 (0.781)

1

1.368 (0.451–4.151), 0.581

1

1.368 (0.451–4.151), 0.581

–––