Fig. 1

Relative positions and linkage disequilibrium estimates between the BDNF polymorphisms. A Linkage equilibrium plot of pairwise SNPs within the BDNF gene in pooled sample. Colored squares correspond to D′ values for each pair of SNPs with numerical estimates given within squares (D′ × 100). Regions of high linkage disequilibrium are shown in black. Markers with lower linkage disequilibrium are shown in tints of gray, with the color intensity decreasing with decreased D′ value. Regions of low linkage disequilibrium are shown in white. Haplotype blocks were defined by the Haploview software with the option of using the haplotype block definition proposed by Gabriel et al. [26, 27]. B Linkage disequilibrium estimates for the revealed block of haplotype. Abbreviations: BDNF, brain-derived neurotrophic factor; SNP, single nucleotide polymorphism