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Table 2 Summary of methods

From: Complexities in liver biopsy: the role of navigation and fusion imaging

Authors

Procedure

Method

Results

Giesel FL et al. 2009 [45]

Radio-frequency ablation

Various imaging modalities were registered and merged + MIPAV software, different algorithms, and visualization tools were used for intra-modality and inter-modality picture registration

Spatial link of lesion anatomy and functional relevance was produced. Fusion axial images and segmentation 3D surface models were employed for treatment, planning, and post-RFA evaluation, optimizing needle placement

Zhao et al. 2020 [50]

Virtual navigation-guided radio- frequency ablation

Prospective study. Key factors were predicted using a multivariate Cox regression analysis, and the overall survival was then predicted using a nomogram with independent predictive factors

Technical feasibility: 86.4% success: 94.7% OS rate at 1-, 2-, and 3-year: 5.5%, 8.7%, and 14.0%, C-index of the OS nomogram: 0.737 no intervention-related deaths

Aoki et al. 2020 [18]

Virtual real-time CT-guided (VRCT) volume navigation during laparoscopic hepatectomies

27 hepatic neoplasms were removed laparoscopically while being monitored by VRCT. To accurately navigate, electromagnetic tracking of the surgical instrument was used

26 lesions (96.3%) with a mean diameter of 11 mm were successfully treated. Using VRCT, the surgeon navigates a liver transection with respectable accuracy

Yasuda et al. 2019 [44]

Laparoscopic surgery using image-guided navigation system

After registration, the 3D models were superimposed on the surgical field

Average registration error: 8.8 mm. The positioning of the tumor and the establishment of the resection line were made simple

Ahn et al. 2016 [51]

Radio-frequency ablation

Technical viability and visibility were evaluated by US imaging. With the use of a separable cluster electrode and a switching monopolar system, RFA was carried out with the aid of fusion imaging

RFA’s technique efficiency for invisible tumors on B-mode US under fusion imaging guidance was comparable to that for visible tumors (96.1% vs. 97.6%, p = 0.295)

Minami et al. 2008 [49]

Radio-frequency ablation

Prospective virtual CT sonography was used to guide radiofrequency ablation on 51 patients with 65 hepatocellular carcinomas. 50 patients with 63 hepatocellular carcinomas treated under B-mode sonographic guidance served as a historical control group

CT sonographic group ablation was achieved in 92% and 8% of patients in one and two sessions respectively. B mode sonography group. Technical success was achieved in 72%, 24%, and 4% of patients in one, two, and three sessions respectively. Technical success rate after a single treatment session was significantly (p = 0.017) higher for the virtual CT sonography group