Fig. 4

Showing that the dysbiosis condition after the patient diagnosed with non-alcoholic fatty liver disease, which results imbalance in gut bacterial population. Initial phase of NAFLD shows upregulation of certain bacterial phyla which are Parabacteroides, Porphyromonas, Bacteroides, Prevotella, Fusobacteria, Lentisphaerae, Robinsoniella, Dorea, Verrucomicrobia, Escherichia, Megasphaera, Bifidobacterium, Shigella, and Eggerthella and decreasing population of Coprobacter, Ruminococcus, Coprococcus, Anaerosporobacter, Faecalibacterium, Moryella, Pseudobutyrivibrio, Eubacterium, Odoribacter, Oscillospira, Subdoligranulum, Holdemania, and Anaerotruncus. When we focus on the NASH stage, several new bacterium phyla detected on progressive stage of the disease and show the increased population of Bacteroides, Allisonella, Proteobacteria, TM7, Klebsiella, and Parabacteroides. Oppositely, there are certain bacterial phyla population which was decreasing which includes Oscillospira, Roseburia, Eubacterium, and Faecalibacterium. Liver fibrosis stage shows decrease bacterial phyla of Bacteroidetes and Verrucomicrobia, whereas the increased population of Bacteroides, Actinobacteria, and Tenericutes reported in end stage of the fatty liver (liver fibrosis)