Fig. 3

Showing that micro-RNA alteration was observed in each stage of the fatty liver disease. Some early-stage-specific micro-RNA like miR-16, miR-1991-5p, miR-193a-5p, and miR-129-5p were highly expressed, and miR-194, miR-135a-3p, and miR-128-p were downregulated [39,40,41,42,43]. Comparatively, in case of NASH, the miR-122-5p, miR-192-5p, miR-4449, miR223, miR-34a, miR-6881-85p, miR-146b, miR-122, and miR-1205 found abundantly expression [44,45,46,47,48,49]. Later stage of the disease like fibrosis/cirrhosis stage also shows some specific upregulation of miRNAs like miR-21, miR-192, and miR-146b [43, 50]