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Table 4 Relation between TCF7L2 SNP with laboratory investigation in cirrhotic diabetes (n = 25)

From: Study of transcription factor 7-like 2 (TCF7L2) gene polymorphism in cirrhotic patients with diabetes

Liver function

TCF7L2

P

CC (n = 3)

CT (n = 18)

TT (n = 4)

ALT(U/L)

 Median (Min.–Max.)

47 (44–63)

45.5 (38–125)

39.5 (35–49)

0.229

AST (U/L)

 Median (Min.–Max.)

67 (58–107)

82 (47–166)

65.5 (56–68)

0.315

Albumin (g/dl)

 Mean ± SD

2.1 ± 0.5

2.6 ± 0.6

2.55 ± 0.5

0.415

Total bilirubin (mg/dl)

 Median (Min.–Max.)

3.4 (1.5–5.5)

3.5 (0.6–8.2)

1.6 (1.6–1.8)

0.245

Direct bilirubin (mg/dl)

 Median (Min.–Max.)

1.3 (0.6–3.5)

1.55 (0.2–5)

0.8 (0.5–0.85)

0.356

INR

 Mean ± SD

1.6 ± 0.3

1.4 ± 0.25

1.5 ± 0.15

0.640

FIB-4 score

 Mean ± SD

6.6 ± 2.2

6.55 ± 2.35

5.3 ± 0.85

0.546

APRI

 Mean ± SD

2.2 ± 0.9

2.1 ± 0.85

1.4 ± 0.3

0.568

Fasting blood glucose(mg/dl)

 Mean ± SD

182.3 ± 6.7

200.7 ± 21.8

221.75 ± 10.7

0.203

HbA1C

 Mean ± SD

8.2 ± 0.5

9.1 ± 1

11.4 ± 0.7

 < 0.001*

 Significance among groups

P1 = 0.311, P2 = 0.001*, P3 = 0.001*

  1. H H for Kruskal–Wallis test, F F for ANOVA test, p p value for comparing between different categories, p1 p value for comparing between CC and CT, p2 p value for comparing between CC and TT, p3, p value for comparing between CT and TT
  2. *Statistically significant at p ≤ 0.05