Table 3 Study the risk of development of DM in different genotypes and alleles
TCF7L2 | DM vs. control | DM vs. cirrhotic | Cirrhotic diabetic vs. control | Cirrhotic diabetic vs. DM | Cirrhotic diabetic vs. cirrhotic | |||||
|---|---|---|---|---|---|---|---|---|---|---|
OR (95% C.I) | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |
Genotypes | ||||||||||
CC® | Ref | – | Ref | Ref | – | Ref | – | Ref | – | |
CT | 3.385 (0.870–13.166) | 0.072 | 2.857 (0.731–11.171) | 0.124 | 5.07 (1.176–21.914) | 0.023* | 1.50 (0.29–7.74) | 0.697 (FE) | 4.29 (0.99–18.59) | 0.043* |
TT | 13.750(1.207 − 156.66) | 0.046*(FE) | 12.500(1.089–143.439) | FEp = 0.049* | 14.67(1.16–185.24) | 0.038*(FE) | 1.067 (0.15–7.82) | 1.000 (FE) | 13.33 (1.05–169.57) | 0.047*(FE) |
Dominant model | ||||||||||
CC® | Ref | – | Ref | Ref | – | Ref | – | Ref | – | |
CT + TT | 4.125 (1.092–15.586) | 0.031* | 3.500 (0.921–13.307) | 0.056 | 5.76 (1.36–24.36) | 0.012* | 1.40 (0.28–7.00) | 1.000 (FE) | 4.89 (1.15–20.79) | 0.024* |
Recessive model | ||||||||||
CC + CT | Ref | – | Ref | - | Ref | – | Ref | – | Ref | – |
TT | 6.00 (0.647–55.664) | 0.189(FE) | 6.000 (0.647–55.664) | FEp = 0.189 | 4.57 (0.47–44.17) | 0.349 (FE) | 0.76 (0.18–3.25) | 1.000 (FE) | 4.57 (0.47–44.17) | 0.349(FE) |
Alleles | ||||||||||
C® | Ref | – | Ref | - | Ref | – | Ref | – | Ref | – |
T | 2.528 (1.112–5.744) | 0.025* | 2.302 (1.021–5.190) | 0.043* | 2.53 (1.11–5.74) | 2.53 (1.11–5.74) | 1.00 (0.46–2.19) | 1.000 (FE) | 2.30 (1.02–5.19) | 0.043* |