Table 1 Comparison between the different studied groups according to clinical data

Gender

 Male

15 (60%)

17 (68%)

13 (52%)

19 (76%)

(0.324)

 Female

10 (40%)

8 (32%)

12 (48%)

6 (24%)

Age (years)

 Mean ± SD

57.8 ± 6.2

56.8 ± 8

59.6 ± 5.1

59 ± 5.3

(0.419)

 Median (Min.–Max.)

58 (46–71)

57 (47–76)

59 (49–68)

59 (48–69)

ALT (U/L)

p1 < 0.001*

p4 < 0.001*

 Mean ± SD

19.6 ± 3

55.1 ± 15.2

19.3 ± 3.3

53.2 ± 20.5

(< 0.001*)

p2 = 0.876

p5 = 0.001*

 Median (Min.–Max.)

20 (12–26)

49 (42–110)

19 (12–25)

45 (35–125)

p3 < 0.001*

p6 < 0.001*

AST (U/L)

p1 < 0.001*

p4 < 0.001*

 Mean ± SD

14.7 ± 3.15

77.7 ± 18.7

14 ± 2.8

85.5 ± 34

(< 0.001*)

p2 = 0.755

p5 = 0.915

 Median (Min.–Max.)

14 (10–20)

75 (56–145)

14 (10–18)

68 (47–166)

p3 < 0.001*

p6 < 0.001*

Albumin (g/dl)

p1 < 0.001*

p4 < 0.001*

 Mean ± SD

4.6 ± 0.3

3.5 ± 0.8

4.3 ± 0.4

2.5 ± 0.55

(< 0.001*)

p2 = 0.338

p5 = 0.001*

 Median (Min.–Max.)

4.6 (3.8–5.1)

3.9 (1.9–4.8)

4.2 (3.8–5)

2.4 (1.5–3.8)

p3 < 0.001*

p6 < 0.001*

Total bilirubin (mg/dl)

p1 < 0.001*

p4 = 0.001*

 Mean ± SD

0.65 ± 0.2

1.7 ± 1.4

0.8 ± 0.2

3.2 ± 2

(< 0.001*)

p2 = 0.166

p5 = 0.049*

 Median (Min.–Max.)

0.7 (0.3–1.1)

1.2 (0.3–6.1)

0.8 (0.5–1.2)

3.2 (0.6–8.2)

p3 < 0.001*

p6 < 0.001*

Direct bilirubin (mg/dl)

p1 < 0.001*

p4 = 0.017*

 Mean ± SD

0.3 ± 0.2

0.8 ± 0.75

0.4 ± 0.15

1.5 ± 1.2

(< 0.001*)

p2 = 0.224

p5 = 0.039*

 Median (Min.–Max.)

0.3 (0.1–0.6)

0.5 (0.1–3.5)

0.4 (0.2–0.7)

1 (0.2–5)

p3 < 0.001*

p6 < 0.001*

WBC (× 10³/cmm)

 Mean ± SD

6.8 ± 1.1

6.5 ± 1.15

7 ± 0.8

7.35 ± 1.5

(0.074)

 > 0.05 (NS)

 > 0.05 (NS)

 Median (Min.–Max.)

6.7 (5–9.1)

6.1 (5–9.2)

7 (5.5–8.2)

7.5 (4.8–9.5)

Platelets (× 10³/cmm)

p1 < 0.001*

p4 < 0.001*

 Mean ± SD

327 ± 63.8

136.9 ± 40.8

456.9 ± 69.7

113.5 ± 34.7

(< 0.001*)

p2 < 0.001*

p5 = 0.428

 Median (Min.–Max.)

310 (240–450)

125 (85–230)

460 (400.0–510.0)

102 (85–210)

p3 < 0.001*

p6 < 0.001*

Hb (g/dl)

p1 < 0.001*

p4 = 0.225

 Mean ± SD

14.5 ± 1.5

12.8 ± 1.8

13.6 ± 1.05

11.6 ± 1.1

(< 0.001*)

p2 = 0.111

p5 = 0.022*

 Median (Min.–Max.)

15.4 (12.4–16.3)

12.4 (10.2–14.9)

13.2 (12.5–15.4)

12 (10.2–13.4)

p3 < 0.001*

p6 < 0.001*

INR

p1 < 0.001*

p4 < 0.001*

 Mean ± SD

1 ± 0

1.3 ± 0.2

1 ± 0.03

1.5 ± 0.2

(< 0.001*)

p2 = 0.998

p5 = 0.002*

 Median (Min.–Max.)

1 (1–1)

1.3 (1–1.7)

1 (1–1.1)

1.4 (1.1–2)

p3 < 0.001*

p6 < 0.001*

Fasting blood glucose (mg/dl)

p1 < 0.001*

p4 < 0.001*

 Mean ± SD

79.5 ± 7

106 ± 9.5

206.8 ± 27.2

201.9 ± 21.7

(< 0.001*)

p2 < 0.001*

p5 < 0.001*

 Median (Min.–Max.)

80 (70–96)

110 (88–115)

200 (175–298)

200 (170–230)

p3 < 0.001*

p6 = 0.780

HbA1C %

p1 = 0.235

p4 < 0.001*

 Mean ± SD

4.8 ± 0.5

5.4 ± 0.4

10.5 ± 1.4

9.3 ± 1.3

(< 0.001*)

p2 < 0.001*

p5 < 0.001*

 Median (Min.–Max.)

4.7 (4–5.8)

5.4 (4.6–5.9)

10.2 (8.6–13)

8.9 (7.6–12.2)

p3 < 0.001*

p6 = 0.001*

FIB-4 score

p1 < 0.001*

p4 < 0.001*

 Mean ± SD

0.6 ± 0.1

4.8 ± 2

0.4 ± 0.1

6.4 ± 2.15

(< 0.001*)

p2 = 0.975

p5 = 0.001*

 Median (Min.–Max.)

0.6 (0.3–0.9)

4.3 (2.3–11)

0.4 (0.3–0.6)

5.8 (2.3–13.2)

p3 < 0.001*

p6 < 0.001*

APRI

p1 < 0.001*

p4 < 0.001*

 Mean ± SD

0.12 ± 0.03

1.5 ± 0.55

0.08 ± 0.02

2 ± 0.8

(< 0.001*)

p2 = 0.993

p5 = 0.013*

 Median (Min.–Max.)

0.11 (0.06–0.19)

1.48 (0.70–2.79)

0.08 (0.04–0.11)

1.74 (0.8–4.15)

p3 < 0.001*

p6 < 0.001*