Table 2 Performance of non-invasive fibrosis markers in the detection of advanced hepatic fibrosis

ALBI score

AUC (95%CI)

0.73 (0.69–0.77)

0.74 (0.71–0.78)

Best cut-off

-2.95

-2.91

Specificity

52.83

53.33

Sensitivity

78.88

80.05

LR + 

1.67

1.71

LR-

0.40

0.37

Accuracy

70.04

67.73

FIB-4 score

AUC (95%CI)

0.85 (0.82–0.88)

0.84 (0.82–0.87)

Best cut-off

1.8

3.25

Specificity

73.21

93.3

Sensitivity

82.17

46.8

LR + 

3.07

7.02

LR-

0.24

0.57

Accuracy

79.13

68.3

APRI score

AUC (95%CI)

0.83 (0.79–0.85)

0.83 (0.80–0.86)

Best cut-off

0.6

0.72

Specificity

63.02

71.7

Sensitivity

81.01

77.2

LR + 

2.19

2.72

LR-

0.30

0.32

Accuracy

74.9

74.65

LOK index

AUC (95%CI)

0.77 (0.74–0.81)

0.76 (0.73–0.79)

Best cut-off

0.4

0.41

Specificity

60.38

57.22

Sensitivity

80.04

80.29

LR + 

2.02

1.88

LR-

0.33

0.34

Accuracy

73.37

69.65

GUCI score

AUC (95%CI)

0.83 (0.80–0.85)

0.83 (0.80–0.86)

Best cut-off

0.52

0.61

Specificity

54.34

55

Sensitivity

88.18

87.17

LR + 

1.93

1.94

LR-

0.22

0.23

Accuracy

76.70

72.34