Clinical value of acoustic radiation force impulse elastography in the prediction of hepatocellular carcinoma in chronic hepatitis C patients

Egyptian Liver Journal

Table 3 Diagnostic performance, optimal cutoffs, and validity of hepatic ARFI, TE, and fibrosis scores for the prediction of HCC among patients with advanced hepatic fibrosis (≥F3) and cirrhosis (F4)

	P value	AUROC (95% CI)	Optimal cutoff	Sensitivity	Specificity	PPV	NPV
Liver stiffness measurement
SWV of hepatic ARFI (m/s)	<0.001	0.80 (2.81–5.76)	2.28	95.6	54.2	35.5	97.4
Hepatic parenchyma stiffness by TE (kPa)	<0.001	0.76 (1.03–1.07)	28.8	65	80.2	26.1	94.6
Fibrosis scores
FIB-4	<0.001	0.76 (1.05–1.18)	3.2	63.7	73.7	35.9	88.2
APRI	<0.001	0.66 (0.98–1.16)	1	67.03	61.7	31.4	87.2
AST/ALT ratio	<0.001	0.72 (2.46–6.03)	1.4	56.04	81.1	43.96	87.4
Age platelets index	<0.001	0.70 (1.26–1.65)	8	70.3	68	34.8	86.6

ARFI Elastography, acoustic radiation force impulse elastography, ALT Alanine aminotransferase, AST Aspartate aminotransferase, APRI Aspartate aminotransferase-to-platelet ratio index, AUC Area under the receiver operating characteristics curve, FIB-4 Fibrosis-4 score, TE Transient elastography, SWV Shear wave velocity