Interaction of peripheral CD4+CD25+CD127− Tregs with prolactin in HCV hepatocellular carcinoma: oncogenic or immunogenic mechanisms

Egyptian Liver Journal

Table 3 The correlation between the frequency of studied T regulatory cell subtypes and clinical and laboratory data

*Variables*	CD4⁺CD25⁺Treg				CD4⁺CD25⁺CD127⁻ Tregs
	Frequency		Expressed mTGFβ₁		Frequency		Expressed mTGFβ₁
	r	P	r	P	r	P	R	P
Age (years)	0.12	0.40	− 0.06	0.674	− 0.01	0.988	− 0.093	0.531
hemoglobin (gm/dl)	0.56	0.001	0.33	0.024	− 0.11	0.437	0.446	0.001
White blood cells × 10³	− 0.08	0.58	0.07	0.648	0.01	0.949	0.137	0.354
Platelets × 10³	0.01	0.94	− 0.06	0.695	− 0.13	0.379	0.047	0.749
Alanine aminotransferase (U/l)	0.03	0.81	0.30	0.038	− 0.14	0.350	0.361	0.012
Aspartate aminotransferase (U/l)	− 0.13	0.37	0.02	0.897	− 0.17	0.251	0.181	0.218
Total billirubin (mg/dl)	− 0.16	0.26	0.08	0.588	0.20	0.166	0.236	0.106
Albumin (gm/dl)	0.39	0.006	0.18	0.055	− 0.28	0.055	0.111	0.453
International normalized ratio	− 0.083	0.57	0.06	0.665	0.005	0.971	0.137	0.353
Serum prolactin (ng/ml)	− 0.03	0.80	− 0.21	0.16	0.08	0.58	− 0.30	0.03

CD cluster differentiation, Tregs T regulatory cells, mTGFβ₁ membrane-bound transforming growth factor β₁
Correlations were performed using non-parametric Spearman test. Bold values indicate statistically significant result