Table 1 Demographic and laboratory features of the studied patients according to the occurrence of hepatic decompensation
Variables | Hepatic decompensation | P-value | ||||
|---|---|---|---|---|---|---|
Yes, number = 184 | No, number = 1605 | |||||
Mean | SD | Mean | SD | |||
Age | 54.21 | 7.29 | 54.89 | 8.58 | 0.201 | |
Gender, number (%) | Male | 105 (57.1%) | 438 (47.5%) | 0.017 | ||
Female | 79 (42.9%) | 485 (52.5%) | ||||
Treatment status | Past interferon treatment | 1 | 0.6% | 4 | 0.5% | 1 |
Naïve | 172 | 97.7% | 863 | 97.5% | ||
Experienced | 3 | 1.7% | 18 | 2.0% | ||
ALT | 64.24 | 39.47 | 63.33 | 42.97 | 0.499 | |
AST | 73.88 | 40.94 | 68.28 | 42.19 | 0.033 | |
Alpha-fetoprotein | 12.02 | 14.16 | 11.95 | 20.61 | 0.209 | |
Serum albumin | 3.79 | 0.57 | 3.97 | 0.67 | < 0.001 | |
Total bilirubin | 1.10 | 0.70 | 0.96 | 0.47 | 0.008 | |
Total leukocytes count × 103 | 5.56 | 3.73 | 6.14 | 4.68 | 0.001 | |
Hemoglobin | 13.16 | 1.64 | 13.57 | 4.41 | 0.029 | |
Platelets count × 103 | 124.46 | 60.97 | 152.71 | 69.25 | < 0.001 | |
Serum creatinine | 0.85 | 0.19 | 1.01 | 3.42 | 0.556 | |
Total bilirubin (during treatment) | 1.22 | 0.59 | 1.07 | 0.57 | < 0.001 | |
Albumin (during treatment) | 3.70 | 0.50 | 3.84 | 0.53 | 0.002 | |
PC (during treatment) | 78.78 | 15.86 | 84.18 | 11.89 | 0.001 | |
INR (during treatment) | 1.98 | 8.22 | 1.15 | 0.16 | 0.122 | |
Total leukocytes count × 103 (during treatment) | 5.14 | 1.87 | 5.53 | 2.02 | 0.042 | |
Platelets count × 103 (during treatment) | 121.26 | 60.53 | 153.55 | 67.12 | < 0.001 | |
Pre-treatment ALBI score | − 2.42 | 0.52 | − 2.61 | 0.59 | < 0.001 | |
Post-treatment ALBI score | − 2.54 | 0.60 | − 2.77 | 1.57 | < 0.001 | |