The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants

Eshiaty, Samah Abdelfatah; Abdelsattar, Shimaa; Sweed, Dina; Abdel-Aziz, Samira A.; Elfert, Ashraf; Elsaid, Hala

doi:10.1186/s43066-023-00244-0

Egyptian Liver Journal

Table 7 Comparison between the two cholestatic groups (BA & non-BA) and control regarding secondary conjugated bile acids in serum and urine (μmol/L)

From: The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants

Secondary conjugated bile acids (μmol/L)		Biliary atresia (n = 37)	Non-biliary atresia (n = 65)	Control (n = 102)	H	p
Serum	Tauroursodeoxycholic acid (TUDCA)
	Min. – Max.	0.0 – 1.3	0.0 – 5.00	0.0 – 0.18	40.991^*	<0.001^*
	Median (IQR)	0.24 (0.0 – 0.45)	0.33 (0.01 – 1.10)	0.06^b (0.01 – 0.13)	40.991^*	<0.001^*
	Taurolithocholic acid (TLCA)
	Min. – Max.	0.0 – 0.64	0.0 – 0.65	0.0 – 0.30	3.853	0.14
	Median (IQR)	0.13 (0.02 – 0.24)	0.10 (0.0 – 0.24)	0.07 (0.0 – 0.13)	3.853	0.14
	Taurodeoxycholic acid (TDCA)
	Min. – Max.	0.0 – 1.78	0.0 – 3.9	0.0 – 0.90	24.17^*	<0.001^*
	Median (IQR)	0.60 (0.20 –.0.50)	0.35 (0.06 – 0.58)	0.14^ab (0.03 –0.16)	24.17^*	<0.001^*
	Glycoursodeoxycholic acid (GUDCA)
	Min. – Max.	0.0 – 4.34	0.0 – 7.3	0.0 – 1.5	30.520^*	<0.001^*
	Median (IQR)	1.0 (0.13 – 2.26)	1.40 (0.15 – 1.20)	0.08^ab (0.03 – 0.27)	30.520^*	<0.001^*
	Glychodeoxycholic acid (GDCA)
	Min. – Max.	0.0 –0.80	0.0 – 0.90	0.0 – 1.40	1.065	0.587
	Median (IQR)	0.2 (0.01 – 0.30)	0.10 (0.01 – 0.31)	0.10 (0.04 – 0.16)	1.065	0.587
Urinary	Tauroursodeoxycholic acid (TUDCA)
	Min. – Max.	0.0 – 0.8	0.0 – 1.6	0.0 – 0.15	30.958^*	<0.001^*
	Median (IQR)	0.0 (0.0 – 0.15)	0.10 (0.0 – 0.20)	0.0^ab (0.0 – 0.01)	30.958^*	<0.001^*
	Taurolithocholic acid (TLCA)
	Min. – Max.	0.0 – 0.19	0.0 – 0.26	0.0 – 1.0	0.397	0.820
	Median (IQR)	0.0 (0.0 – 0.0)	0.0 (0.0 – 0.02)	0.0 (0.0 – 0.02)	0.397	0.820
	Taurodeoxycholic acid (TDCA)
	Min. – Max.	0.0 – 0.50	0.0 – 0.70	0.0 – 0.20	5.646	0.059
	Median (IQR)	0.03 (0.0 – 0.15)	0.0 (0.0 – 0.12)	0.0 (0.0 – 0.07)	5.646	0.059
	Glycoursodeoxycholic acid (GUDCA)
	Min. – Max.	0.0 – 0.9	0.0 – 7.2	0.0 – 0.20	54.651^*	<0.001^*
	Median (IQR)	0.20 (0.0 – 0.55)	0.40 (0.01–1.35)	0.0^ab (0.0 – 0.02)	54.651^*	<0.001^*
	Glychodeoxycholic acid (GDCA)
	Min. – Max.	0.0 – 0.37	0.0 – 0.3	0.0 – 0.30	4.731	0.094
	Median (IQR)	0.0 (0.0 – 0.06)	0.0 (0.0 – 0.01)	0.0 (0.0 – 0.02)	4.731	0.094

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