Table 6 Comparison between the two cholestatic groups (BA & non-BA) and control regarding secondary unconjugated bile acids in serum and urine (μmol/L)
From: The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants
Secondary unconjugated bile acids (μmol/L) | Biliary atresia (n = 37) | Non-biliary atresia (n = 65) | Control (n = 102) | H | p | |
|---|---|---|---|---|---|---|
Serum | Ursodeoxycholic acid (UDCA) | |||||
 Min. – Max. | 0.0 – 0.12 | 0.0 – 1.20 | 0.0 – 0.13 | 0.15 | 0.926 | |
 Median (IQR) | 0.01 (0.0 – 0.06) | 0.01 (0.0 – 0.07) | 0.01 (0.0 – 0.04) | |||
Lithocholic acid (LCA) | ||||||
 Min. – Max. | 0.0 – 0.60 | 0.0 – 0.5 | 0.0 – 0.48 | 3.169 | 0.205 | |
 Median (IQR) | 0.03 (0.0 – 0.10) | 0.01 (0.0 – 0.10) | 0.05 (0.0 – 0.09) | |||
Deoxycholic acid (DCA) | ||||||
 Min. – Max. | 0.0 – 0.56 | 0.0 – 1.40 | 0.0 – 0.40 | 15.08* | <0.001* | |
 Median (IQR) | 0.02 (0.0 – 0.09) | 0.01 (0.0 – 0.10) | 0.07ab (0.02 –0.11) | |||
Urinary | Ursodeoxycholic (UDCA) | |||||
 Min. – Max. | 0.0 – 0.15 | 0.0 – 1.40 | 0.0 – 0.04 | 18.129* | <0.001* | |
 Median (IQR) | 0.0 (0.0 – 0.01) | 0.0 (0.0 – 0.02) | 0.0ab (0.0 – 0.0) | |||
Lithocholic acid (LCA) | ||||||
 Min. – Max. | 0.0 – 0.49 | 0.0 – 0.36 | 0.0 – 0.10 | 0.014 | 0.993 | |
 Median (IQR) | 0.0 (0.0 – 0.0) | 0.0 (0.0 – 0.0) | 0.0 (0.0 – 0.02) | |||
Deoxycholic acid (DCA) | ||||||
 Min. – Max. | 0.0 – 0.18 | 0.0 – 0.20 | 0.0 – 0.30 | 3.724 | 0.155 | |
 Median (IQR) | 0.0 (0.0 – 0.0) | 0.0 (0.0 – 0.0) | 0.0 (0.0 – 0.01) | |||