From: The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants
Primary conjugated bile acids (μmol/L) | Biliary atresia (n = 37) | Non-biliary atresia (n = 65) | Control (n = 102) | H | p | |
---|---|---|---|---|---|---|
Serum | Glycholic acid (GCA) | |||||
 Min. – Max. | 0.80 – 144.0 | 0.0 – 281.0 | 0.0 – 3.0 | 126.824* | <0.001* | |
 Median (IQR) | 22.9(14.60 – 44.0) | 18.0 (6.60 – 40.30) | 0.10ab (0.02-0.70) | |||
Glychochenodeoxycholic acid (GCDCA) | ||||||
 Min. – Max. | 6.80 – 163.0 | 0.02 – 167.0 | 0.0 – 2.50 | 130.766* | <0.001* | |
 Median (IQR) | 42 (30.20 – 66.30) | 22.80a (12.2 -52.0) | 0.08ab (0.04 -0.60) | |||
Taurochlolic acid (TCA) | ||||||
 Min. – Max. | 0.12 – 155.70 | 0.0 – 65.90 | 0.0 – 0.86 | 113.598* | <0.001* | |
 Median (IQR) | 24.7 (12.80 -39.8) | 17.8a (4.2 -32.9) | 0.06ab (0.01 –0.21) | |||
Taurochenodeoxycholic acid (TCDCA) | ||||||
 Min. – Max. | 0.13 – 183.0 | 0.0 – 208.0 | 0.0 – 1.30 | 113.738* | <0.001* | |
 Median (IQR) | 45.0 (36.90 –68.60) | 20.5a (9.0 – 45.50) | 0.03ab (0.0 – 0.50) | |||
TCDCA/CDCD ratio | ||||||
 Min. – Max. | 13.0 – 11920.0 | 0.0 – 20800.0 | 0.40 – 100.0 | 116.004* | <0.001* | |
 Median (IQR) | 686.0(260.0– 2740) | 683.33(91.4 -2420) | 9.0ab (3.58 – 20.0) | |||
GCDCA/CDCA ratio | ||||||
 Min. – Max. | 230.0 – 16300.0 | 0.25 – 16700.0 | 0.50 – 600.0 | 124.972* | <0.001* | |
 Median (IQR) | 3860.0(2240 -6300) | 1720.0a (404.2-3640) | 22.50ab (8.0 –85.0) | |||
Urinary | Glycholic acid (GCA) | |||||
 Min. – Max. | 0.0 – 68.0 | 0.0 – 64.50 | 0.0 – 3.0 | 101.57* | <0.001* | |
 Median (IQR) | 6.60 (3.10 – 18.0) | 6.30(1.40– 12.50) | 0.10ab (0.02 –0.70) | |||
Glychochenodeoxycholic acid (GCDCA) | ||||||
 Min. – Max. | 0.0 – 67.0 | 0.0 – 52.0 | 0.0 – 2.50 | 36.142* | <0.001* | |
 Median (IQR) | 8.60 (0.30 – 17.0) | 0.60 (0.15 – 7.40) | 0.08ab (0.04 – 0.60) | |||
Taurochlolic acid (TCA) | ||||||
 Min. – Max. | 0.0 – 83.80 | 0.0 – 33.0 | 0.0 – 0.86 | 103.752* | <0.001* | |
 Median (IQR) | 5.60 (2.40– 17.40) | 2.60 (0.44 – 9.50) | 0.06ab (0.01 –0.21) | |||
Taurochenodeoxycholic acid (TCDCA) | ||||||
 Min. – Max. | 0.0 – 56.70 | 0.0 – 65.60 | 0.0 – 1.30 | 55.941* | <0.001* | |
 Median (IQR) | 1.20 (0.20 – 17.0) | 0.60 (0.17 – 6.30) | 0.03ab (0.0 – 0.50) |