The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants

Egyptian Liver Journal

Table 4 Comparison between the two cholestatic groups (BA & non-BA) and control regarding primary unconjugated bile acids in serum and urine (μmol/L)

Primary unconjugated bile acids (μmol/L)		Biliary atresia (n = 37)	Non-biliary atresia (n = 65)	Control (n = 102)	H	p
Serum	Cholic acid (CA)
	Min. – Max.	0.0 – 0.23	0.0 – 1.20	0.0 – 0.50	12.19^*	0.002^*
	Median (IQR)	0.09 (0.0 – 0.11)	0.05 (0.01 – 0.190)	0.13^a (0.07 – 0.21	12.19^*	0.002^*
	Chenodeoxycholic acid (CDCA)
	Min. – Max.	0.0–0.24	0.0 – 0.9	0.0 – 0.90	16.1961^*	<0.001^*
	Median (IQR)	0.05 (0.01 – 0.09)	0.01 (0.0 – 0.12)	0.0 ^a (0.0 – 0.03)	16.1961^*	<0.001^*
Urinary	Cholic acid (CA)
	Min. – Max.	0.0 – 0.20	0.0 – 0.80	0.0 – 0.30	0.244	0.885
	Median (IQR)	0.0 (0.0 – 0.04)	0.0 (0.0 – 0.04)	0.0 (0.0 – 0.03)	0.244	0.885
	Chenodeoxycholic acid (CDCA)
	Min. – Max.	0.0–0.13	0.0–0.40	0.0–0.90	2.012	0.366
	Median (IQR)	0.0 (0.0–0.01)	0.0 (0.0–0.01)	0.0 (0.0–0.03)	2.012	0.366

H H for Kruskal-Wallis test, pairwise comparison bet. 2 groups was done using post hoc test (Dunn’s for multiple comparisons test)
IQR Interquartile range, SD Standard deviation
p p value for comparing the studied groups
*Statistically significant at p ≤ 0.05
^aStatistically significant with the biliary atresia group
^bStatistically significant with the non-biliary atresia group