Skip to main content

Table 2 Comparison between the pathological findings in the two cholestatic groups (biliary atresia and non-biliary)

From: The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants

 

Biliary atresia (n= 37)

Non-biliary atresia (n = 32)

χ2

p

No.

%

No.

%

Visible bile plug

 Absent

1

(2.7)

14

(43.8)

29.507*

<0.001*

 Bile duct

0

(0.0)

3

(9.4)

 Canalicular

10

(27.0)

10

(31.3)

 Bile duct and canalicular

26

(70.3)

5

(15.6)

Portal tract edema

 Absent

4

(10.8)

25

(78.1)

31.912*

<0.001*

 Present

33

(89.2)

7

(21.9)

Portal tract fibrosis

 Absent or fibrous expansion of some portal area

3

(8.1)

19

(59.4)

34.232*

<0.001*

 Fibrous expansion of most portal area

7

(18.9)

11

(34.4)

 Focal portal to portal bridging

16

(43.2)

2

(6.3)

 Marked bridging

11

(29.7)

0

(0.0)

Portal tract inflammation

 Absent

0

(0.0)

6

(18.8)

10.247*

MCp=0.004*

 Mild

15

(40.5)

16

(50.0)

 Moderate

22

(59.5)

10

(31.3)

Periductular neutrophils

 Absent

3

(8.1)

19

(59.4)

24.709*

<0.001*

 Mild

22

(59.5)

12

(37.5)

 Marked

12

(32.4)

1

(3.1)

Ductular proliferation

 None

1

(2.7)

12

(37.5)

41.999*

<0.001*

 Focal

5

(13.3)

18

(56.3)

 Generalized

31

(83.8)

2

(6.3)

Mononuclear inflammatory cells in duct

 Absent

3

(8.1)

21

(65.6)

25.868*

<0.001*

 Mild

12

(59.5)

9

(28.1)

 Multiple

222

(32.4)

2

(6.3)

Hepatocytes swelling

 Absent

17

(45.9)

11

(34.4)

9.422*

0.009*

 Less than 50%

18

(48.6)

11

(34.4)

 More than 50%

2

(5.4)

10

(31.3)

 

Pseudo-rosette formation

 Absent

2

(5.4)

11

(34.4)

14.930*

MCp=0.001*

 Present

34

(91.9)

16

(50.0)

 Prominent

1

(2.7)

5

(15.6)

Hepatocyte multinucleated giant cells

 Absent

22

(59.5)

9

(28.1)

12.464*

0.002*

 Present

13

(35.1)

11

(34.4)

 Prominent

2

(5.4)

12

(37.5)

Extramedullary hematopoiesis

 Absent

31

(83.8)

19

(59.4)

6.811*

MCp=0.018*

 Present

6

(16.2)

4

(12.5)

 Extensive

0

(0.0)

9

(28.1)

Steatosis

 Absent

36

(97.3)

28

(87.5)

2.451

FEp=0.175

 Present

1

(2.7)

4

(12.5)

Lobular necroinflammation

 Absent

330

(81.1)

18

(56.3)

5.082

MCp=0.077

 Few

5

(13.5)

11

(34.4)

 Many

2

(5.4)

3

(9.4)

  1. FE Fisher’s exact, MC Monte Carlo