From: The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants
 | Biliary atresia (n= 37) | Non-biliary atresia (n = 32) | χ2 | p | ||
---|---|---|---|---|---|---|
No. | % | No. | % | |||
Visible bile plug | ||||||
 Absent | 1 | (2.7) | 14 | (43.8) | 29.507* | <0.001* |
 Bile duct | 0 | (0.0) | 3 | (9.4) | ||
 Canalicular | 10 | (27.0) | 10 | (31.3) | ||
 Bile duct and canalicular | 26 | (70.3) | 5 | (15.6) | ||
Portal tract edema | ||||||
 Absent | 4 | (10.8) | 25 | (78.1) | 31.912* | <0.001* |
 Present | 33 | (89.2) | 7 | (21.9) | ||
Portal tract fibrosis | ||||||
 Absent or fibrous expansion of some portal area | 3 | (8.1) | 19 | (59.4) | 34.232* | <0.001* |
 Fibrous expansion of most portal area | 7 | (18.9) | 11 | (34.4) | ||
 Focal portal to portal bridging | 16 | (43.2) | 2 | (6.3) | ||
 Marked bridging | 11 | (29.7) | 0 | (0.0) | ||
Portal tract inflammation | ||||||
 Absent | 0 | (0.0) | 6 | (18.8) | 10.247* | MCp=0.004* |
 Mild | 15 | (40.5) | 16 | (50.0) | ||
 Moderate | 22 | (59.5) | 10 | (31.3) | ||
Periductular neutrophils | ||||||
 Absent | 3 | (8.1) | 19 | (59.4) | 24.709* | <0.001* |
 Mild | 22 | (59.5) | 12 | (37.5) | ||
 Marked | 12 | (32.4) | 1 | (3.1) | ||
Ductular proliferation | ||||||
 None | 1 | (2.7) | 12 | (37.5) | 41.999* | <0.001* |
 Focal | 5 | (13.3) | 18 | (56.3) | ||
 Generalized | 31 | (83.8) | 2 | (6.3) | ||
Mononuclear inflammatory cells in duct | ||||||
 Absent | 3 | (8.1) | 21 | (65.6) | 25.868* | <0.001* |
 Mild | 12 | (59.5) | 9 | (28.1) | ||
 Multiple | 222 | (32.4) | 2 | (6.3) | ||
Hepatocytes swelling | ||||||
 Absent | 17 | (45.9) | 11 | (34.4) | 9.422* | 0.009* |
 Less than 50% | 18 | (48.6) | 11 | (34.4) | ||
 More than 50% | 2 | (5.4) | 10 | (31.3) |  | |
Pseudo-rosette formation | ||||||
 Absent | 2 | (5.4) | 11 | (34.4) | 14.930* | MCp=0.001* |
 Present | 34 | (91.9) | 16 | (50.0) | ||
 Prominent | 1 | (2.7) | 5 | (15.6) | ||
Hepatocyte multinucleated giant cells | ||||||
 Absent | 22 | (59.5) | 9 | (28.1) | 12.464* | 0.002* |
 Present | 13 | (35.1) | 11 | (34.4) | ||
 Prominent | 2 | (5.4) | 12 | (37.5) | ||
Extramedullary hematopoiesis | ||||||
 Absent | 31 | (83.8) | 19 | (59.4) | 6.811* | MCp=0.018* |
 Present | 6 | (16.2) | 4 | (12.5) | ||
 Extensive | 0 | (0.0) | 9 | (28.1) | ||
Steatosis | ||||||
 Absent | 36 | (97.3) | 28 | (87.5) | 2.451 | FEp=0.175 |
 Present | 1 | (2.7) | 4 | (12.5) | ||
Lobular necroinflammation | ||||||
 Absent | 330 | (81.1) | 18 | (56.3) | 5.082 | MCp=0.077 |
 Few | 5 | (13.5) | 11 | (34.4) | ||
 Many | 2 | (5.4) | 3 | (9.4) |