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Table 2 Comparison between each group before and after treatment and the two studied groups according to liver profile

From: Impact of direct-acting antiviral therapy on metabolic profiles and adiponectin serum level in different categories of patients with chronic hepatitis C infection

  Groups T test
Group I Group II t P value
AST
Before
  Range 30–83 U/L 13–40 U/L 11.966 <0.001*
  Mean ± SD 58.6 ± 15.1 U/L 29.680 ± 8.077 U/L
After
  Range 34–80 U/L 17–40 U/L 12.733 <0.001*
  Mean ± SD 56.500 ± 12.402 U/L 31.140 ± 6.673 U/L
Differences
  Mean ± SD 2.160 ± 5.227 U/L − 1.460 ± 4.057 U/L   
Paired test
  Pvalue 0.005* 0.014*  
ALT
Before
  Range 29–92 U/L 14–40 U/L 12.902 <0.001*
  Mean ± SD 59.300 ± 15.289 U/L 26.880 ± 9.052 U/L
After
  Range 26–81 U/L 15–39 U/L 13.615 <0.001*
  Mean ± SD 55.340 ± 12.639 U/L 27.240 ± 7.297 U/L
Differences
  Mean ± SD 3.960 ± 5.533 U/L − 0.360 ± 3.533 U/L   
Paired test
  Pvalue <0.001* 0.475  
Total bilirubin
Before
  Range 0.7–1.67 mg/dL 0.3–1.3 mg/dL 9.399 <0.001*
  Mean ± SD 1.276 ± 0.215 mg/dL 0.747 ± 0.335 mg/dL
After
  Range 0.8–1.7 mg/dL 0.29–1.19 mg/dL 10.529 <0.001*
  Mean ± SD 1.236 ± 0.204 mg/dL 0.743 ± 0.260 mg/dL
Differences
  Mean ± SD 0.041 ± 0.078 mg/dL 0.003 ± 0.135 mg/dL   
Paired test
  Pvalue 0.001* 0.860  
Serum albumin
Before
  Range 2.6–4 g/L 3.5–4.7 g/L − 11.989 <0.001*
  Mean ± SD 3.256 ± 0.315 g/L 3.986 ± 0.293 g/L
After
  Range 2.8–3.9 g/L 3.6–4.4 g/L − 12.021 <0.001*
  Mean ± SD 3.312 ± 0.303 g/L 3.948 ± 0.219 g/L
Differences
  Mean ± SD − 0.056 ± 0.142 g/L 0.038 ± 0.261 g/L   
Paired test
  Pvalue 0.007* 0.308  
INR
Before
  Range 0.62–1.7 0.79–1.4 3.046 0.003*
  Mean ± SD 1.212 ± 0.212 1.098 ± 0.159
After
  Range 0.73–1.59 0.67–1.37 4.424 <0.001*
  Mean ± SD 1.171 ± 0.191 1.013 ± 0.166
Differences
  Mean ± SD 0.041 ± 0.074 0.085 ± 0.047   
Paired test
  Pvalue <0.001* <0.001*  
  1. t Student’s t test, p p value for comparing between the two groups, AST aspartate aminotransferase, ALT alanine aminotransferase, INR international normalized ratio
  2. *highly significant