Table 2 Comparison between each group before and after treatment and the two studied groups according to liver profile

AST

 Before

  Range

30–83 U/L

13–40 U/L

11.966

<0.001*

  Mean ± SD

58.6 ± 15.1 U/L

29.680 ± 8.077 U/L

 After

  Range

34–80 U/L

17–40 U/L

12.733

<0.001*

  Mean ± SD

56.500 ± 12.402 U/L

31.140 ± 6.673 U/L

 Differences

  Mean ± SD

2.160 ± 5.227 U/L

− 1.460 ± 4.057 U/L

 Paired test

  Pvalue

0.005*

0.014*

ALT

 Before

  Range

29–92 U/L

14–40 U/L

12.902

<0.001*

  Mean ± SD

59.300 ± 15.289 U/L

26.880 ± 9.052 U/L

 After

  Range

26–81 U/L

15–39 U/L

13.615

<0.001*

  Mean ± SD

55.340 ± 12.639 U/L

27.240 ± 7.297 U/L

 Differences

  Mean ± SD

3.960 ± 5.533 U/L

− 0.360 ± 3.533 U/L

 Paired test

  Pvalue

<0.001*

0.475

Total bilirubin

 Before

  Range

0.7–1.67 mg/dL

0.3–1.3 mg/dL

9.399

<0.001*

  Mean ± SD

1.276 ± 0.215 mg/dL

0.747 ± 0.335 mg/dL

 After

  Range

0.8–1.7 mg/dL

0.29–1.19 mg/dL

10.529

<0.001*

  Mean ± SD

1.236 ± 0.204 mg/dL

0.743 ± 0.260 mg/dL

 Differences

  Mean ± SD

0.041 ± 0.078 mg/dL

0.003 ± 0.135 mg/dL

 Paired test

  Pvalue

0.001*

0.860

Serum albumin

 Before

  Range

2.6–4 g/L

3.5–4.7 g/L

− 11.989

<0.001*

  Mean ± SD

3.256 ± 0.315 g/L

3.986 ± 0.293 g/L

 After

  Range

2.8–3.9 g/L

3.6–4.4 g/L

− 12.021

<0.001*

  Mean ± SD

3.312 ± 0.303 g/L

3.948 ± 0.219 g/L

 Differences

  Mean ± SD

− 0.056 ± 0.142 g/L

0.038 ± 0.261 g/L

 Paired test

  Pvalue

0.007*

0.308

INR

 Before

  Range

0.62–1.7

0.79–1.4

3.046

0.003*

  Mean ± SD

1.212 ± 0.212

1.098 ± 0.159

 After

  Range

0.73–1.59

0.67–1.37

4.424

<0.001*

  Mean ± SD

1.171 ± 0.191

1.013 ± 0.166

 Differences

  Mean ± SD

0.041 ± 0.074

0.085 ± 0.047

 Paired test

  Pvalue

<0.001*

<0.001*