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Egyptian Liver Journal

Table 3 Pairwise comparison between baseline, SVR 24, and SVR 48 at group A regarding labs, scores, and abdominal US

From: Impact of sustained virologic response in regression of portal hypertension in Egyptian patients with hepatitis C virus-associated cirrhosis and portal hypertension

Variables

Group A

Pairwise comparisons

Baseline

SVR24

SVR48

Mean difference (p-value)

Mean ± SD

Median (IQR)

Mean ± SD

Median (IQR)

Mean ± SD

Median (IQR)

Baseline vs. SVR 24

SVR 24 vs. SVR 48

Baseline vs. SVR 48

Laboratory values

 AST (IU/L)

78.8 ± 46.53

41.7 ± 14.72

33.23 ± 5.73

−37.1 (< 0.001)

−8.48 (0.004)

−45.58 (< 0.001)

 ALT (IU/L)

55.78 ± 38.17

34.9 ± 11.97

26.6 ± 6.77

−20.88 (< 0.001)

−8.3 (< 0.001)

−29.18 (< 0.001)

 T. bilirubin (mg/dL)

1.6 ± 0.88

1.4 ± 0.65

1.29 ± 0.57

−0.2 (< 0.001)

−0.11 (< 0.001)

−0.31 (< 0.001)

 Serum albumin (g/dL)

2.88 ± 0.47

3.15 ± 0.44

3.42 ± 0.33

0.27 (< 0.001)

0.27 (< 0.001)

0.55 (< 0.001)

 INR

1.35 ± 0.19

1.3 ± 0.19

1.25 ± 0.17

−0.06 (0.007)

−0.05 (0.047)

−0.1 (< 0.001)

 Platelet count × 103/mm

80.5 ± 19.05

95.88 ± 20.99

100.95 ± 21.7

15.38 (< 0.001)

5.08 (< 0.001)

20.45 (< 0.001)

Noninvasive scores

 Child-Pugh score

7.68 ± 1.27

6.8 ± 1.14

6.5 ± 1.18

−0.88 (< 0.001)

−0.3 (0.008)

−1.18 (< 0.001)

 APRI score

2.77 ± 1.8

1.24 ± 0.57

0.95 ± 0.37

−1.53 (< 0.001)

−0.29 (< 0.001)

−1.82 (< 0.001)

 AAR

1.83 ± 2.07

1.25 ± 0.37

1.3 ± 0.26

−0.58 (0.021)

0.05 (1.00)

−0.54 (0.07)

 PC/SD ratio

525 ± 166

636 ± 198

675 ± 200

112 (< 0.001)

38 (< 0.001)

150 (< 0.001)

 FIB-4 index

8.19 ± 5.3

4.36 ± 1.68

3.79 ± 1.25

−3.84 (< 0.001)

−0.57 (0.001)

−4.4 (< 0.001)

 King’s score

76.99 ± 47.32

33.03 ± 14.51

23.98 ± 8.08

−43.96 (< 0.001)

−9.05 (< 0.001)

−53.01 (< 0.001)

 Lok index

3.16 ± 2.89

1.99 ± 1.23

1.77 ± 1.05

−1.17 (< 0.001)

−0.22 (0.169)

−1.39 (< 0.001)

Abdominal US

 Spleen diameter (cm)

15.74 ± 1.53

15.48 ± 1.51

15.35 ± 1.49

< 0.001

< 0.001

0.003

 Degree of ascites

No

5 (12.5%)

18 (45%)

25 (62.5%)

< 0.001

< 0.001

0.008

Mild

15 (37.5%)

18 (45%)

11 (27.5%)

Moderate

9 (22.5%)

4 (10%)

4 (10%)

Tense

11 (27.5%)

0 (0%)

0 (0%)

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