Impact of sustained virologic response in regression of portal hypertension in Egyptian patients with hepatitis C virus-associated cirrhosis and portal hypertension

Faheem, Heba Ahmed; Abdulmeged, Nannes Adel; Hussein, Hany Aly; Elmoursi, Ahmed Abdelaziz; Elnaggar, Heba T-allah Mohammed Yousry; Ghait, Ramy Samir

doi:10.1186/s43066-022-00188-x

Egyptian Liver Journal

Table 1 Baseline characteristic data of the studied groups

From: Impact of sustained virologic response in regression of portal hypertension in Egyptian patients with hepatitis C virus-associated cirrhosis and portal hypertension

Variables		Group A	Group B	Test of significance
Variables		N (%) Mean ± SD Median (IQR)	N (%) Mean ± SD Median (IQR)	Value	p-Value
Baseline demographic data
Age		55.98 ± 11.46	57.45 ± 10.21	*t =* −0.608	0.545
Gender	Male	16 (40%)	12 (30%)	X²= 0.879	0.348
Gender	Females	24 (60%)	28 (70%)	X²= 0.879	0.348
SVR	SVR 12	40 (100%)	40 (100%)	-	-
SVR	SVR 24	40 (100%)	40 (100%)	-	-
Child-Pugh score	Child A	6 (15%)	40 (100%)	-	-
Child-Pugh score	Child B	34 (85%)	-	-	-
Baseline laboratory values
AST (IU/L)		78.8 ± 46.53	83.7 ± 46.64	z = −0.390	0.697
ALT (IU/L)		55.78 ± 38.17	53.18 ± 30.4	z = −0.034	0.973
T. bilirubin (mg/dL)		1.6 ± 0.88	1.25 ± 0.5	z = −1.628	0.103
Serum albumin (g/dL)		2.88 ± 0.47	3.38 ± 0.45	t = −4.866	< 0.001
INR		1.35 ± 0.19	1.26 ± 0.16	t = 2.341	0.022
Platelet count × 10³/mm		80.5 ± 19.05	109.3 ± 13.41	t = −7.818	< 0.001
Baseline noninvasive markers
Child-Pugh classification		7.68 ± 1.27	5.7 ± 0.46	t = 9.246	< 0.001
APRI score		2.77 ± 1.8	2.21 ± 1.3	z = −1.549	0.121
AAR		1.83 ± 2.07	1.68 ± 0.53	z = −1.126	0.260
PC/SD ratio		525 ± 166	828 ± 154	t = −8.467	< 0.001
FIB-4 index		8.19 ± 5.3	5.95 ± 1.9	z = −2.540	0.011
King’s score		76.99 ± 47.32	54.45 ± 30.06	z = −2.252	0.024
Lok index		3.16 ± 2.89	2.23 ± 0.99	z = −2.107	0.035
Baseline abdominal US
Liver texture	Coarse	0 (0%)	12 (30%)	X²= 14.118	< 0.001
Liver texture	Cirrhotic	40 (100%)	28 (70%)	X²= 14.118	< 0.001
Spleen diameter (cm)		15.74 ± 1.53	13.34 ± 0.96	*t =* 8.369	< 0.001
Degree of ascites	No	5 (12.5%)	40 (100%)	Fisher’s exact test	< 0.001
	Mild	15 (37.5%)	0 (0%)
	Moderate	9 (22.5%)	0 (0%)
	Tense	11 (27.5%)	0 (0%)
Baseline portal and hepatic veins duplex
PV diameter (mm)		14.41 ± 1.04	11.53 ± 1.42	*t =* 10.343	< 0.001
PV velocity (cm/s)		12.44 ± 1.98	18.39 ± 1.76	*t =* −14.201	< 0.001
Hepatic vein waveform	Monophasic	26 (65%)	0 (0%)	Fisher’s exact test	< 0.001
	Biphasic	8 (20%)	0 (0%)
	Triphasic	6 (15%)	40 (100%)
Collaterals	Yes	6 (15%)	0 (0%)	Fisher’s exact test	0.026
Collaterals	No	34 (85%)	40 (100%)	Fisher’s exact test	0.026

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