Skip to main content
Egyptian Liver Journal

Table 1 Demographic, clinical, and laboratory characteristics of the study groups

From: Do old urinary biomarkers have a place in the new definition of hepatorenal syndrome in the Egyptian cirrhotic patients? A single-center experience

 

Group I (n = 40)

Group II (n = 60)

Group III (n = 60)

P-value

aAge (years)

 Range

(40–60)

(38–63)

(41–62)

0.943

 Mean ± SD

52.2 ± 5.11

49.7 ± 7.31

53.8 ± 5.6

 

cSex

 Male

14 (70%)

21 (70%)

22 (73.3%)

0.950

 Female

6 (30%)

9 (30%)

8 (26.7%)

 

aSBP (mmHg)

   

0.007*

 Range

(100–120)

(100–120)

(100–120)

I vs II

I vs III

II vs III

 Mean ± SD

109.75 ± 7.15

110.16 ± 6.08

105.16 ± 6.22

1

0.047*

0.010*

aDBP (mmHg)

 Range

(60–80)

(60–80)

(60–80)

0.145

 Mean ± SD

72 ± 6.15

70.66 ± 5.21

69 ± 4.81

 

aMAP (mmHg)

   

0.026*

 Range

(73–93)

(73–93)

(73–93)

I vs II

I vs III

II vs III

 Mean ± SD

84.5 ± 5.87

83.66 ± 4.8

80.86 ± 4.62

1

0.043*

0.102

bHospital stay (days)

   

< 0.001*

 Median

4

6

8.5

I vs II

I vs III

II vs III

 IR

(0–5)

(4–7)

(7–11)

0.092

< 0.001*

0.001*

dHematemesis (n, %)

   

0.014*

 No

9 (45%)

3 (10%)

5 (16.7%)

I vs II

I vs III

II vs III

 Yes

11 (55%)

27 (90%)

25 (83.3%)

0.007*

0.029*

0.706

dEncephalopathy (n, %)

   

< 0.001*

 No

17 (85%)

18 (60%)

3 (10%)

I vs II

I vs III

II vs III

 Yes

3 (15%)

12 (40%)

27 (90%)

0.069

< 0.001*

< 0.001*

dSpontaneous bacterial peritonitis (n, %)

   

0.008*

 No

20 (100%)

27 (90%)

21 (70%)

I vs II

I vs III

II vs III

 Yes

0 (0%)

3 (10%)

9 (30%)

0.265

0.007*

0.104

aHb (gm/dl)

   

0.005*

 Range

(6.8–14.8)

(5.4–14.4)

(5.1–16.5)

I vs II

I vs III

II vs III

 Mean ± SD

11.63 ± 1.81

10.29 ± 1.97

9.58 ± 2.46

0.097

0.004*

0.606

aHCT (%)

   

0.004*

 Range

(22.5–42.5)

(16.5–45)

(14.5–47.9)

I vs II

I vs III

II vs III

 Mean ± SD

34.18 ± 4.73

30.75 ± 6.37

27.83 ± 7.39

0.206

0.003*

0.249

aWBCs (cells/cmm3) (× 103)

 Range

(1–10.5)

(1–16)

(1–21)

0.493

 Mean ± SD

5.98 ± 2.34

6.86 ± 3.73

7.27 ± 4.5

 

aPlatelets (cells/cmm3) (× 103)

   

0.029*

 Range

(54–423)

(39–270)

(29–210)

I vs II

I vs III

II vs III

 Mean ± SD

150.45 ± 88.02

114.4 ± 54.84

102.83 ± 45.42

0.141

0.028*

1

aSerum albumin (gm/dl)

   

< 0.001*

 Range

(1.9–4.7)

(1.6–3.9)

(1.3–3.4)

I vs II

I vs III

II vs III

 Mean ± SD

3.12 ± 0.96

2.54 ± 0.56

2.2 ± 0.57

0.015*

< 0.001*

0.165

aTotal protein (gm/dl)

   

< 0.001*

 Range

(3.9–8.5)

(3.5–7.7)

(3.8–7.6)

I vs II

I vs III

II vs III

 Mean ± SD

6.63 ± 1.08

6.12 ± 1.01

5.57 ± 1.05

0.289

0.002*

0.131

bTotal bilirubin (mg/dl)

   

< 0.001*

 Median

1.4

2.65

3.85

I vs II

I vs III

II vs III

 IR

(0.7–2.35)

(1.57–3.3)

(2.75–5.57)

0.148

< 0.001*

0.020*

bDirect bilirubin (mg/dl)

   

< 0.001*

 Median

0.9

1.2

2.15

I vs II

I vs III

II vs III

 IR

(0.23–1.39)

(0.67–1.6)

(1.2–4.22)

0.376

< 0.001*

0.006*

bALT (IU/L)

 Median

41.05

28.5

37.75

 

 IR

(28.25–78.42)

(20.75–48.25)

(24.75–58.75)

0.267

bAST (IU/L)

 Median

56

43.5

57.85

0.317

 IR

(38.8–92.65)

(33.25–89.25)

(45–97.5)

 

aINR

   

0.005*

 Range

(1–3.9)

(1.2–2.8)

(1.2–2.9)

I vs II

I vs III

II vs III

 Mean ± SD

1.48 ± 0.63

1.64 ± 0.37

1.94 ± 0.49

0.779

0.006*

0.061

aCPT score

   

< 0.001*

 Range

(5–12)

(6–13)

(9–14)

I vs II

I vs III

II vs III

 Mean ± SD

6.85 ± 1.75

9.56 ± 1.69

11.7 ± 1.41

< 0.001*

< 0.001*

< 0.001*

cCPT class (n, %)

 Class A

11 (55%)

1 (3.3%)

0 (0%)

< 0.001*

 Class B

8 (40%)

10 (33.3%)

2 (6.7%)

I vs II

I vs III

II vs III

 Class C

1 (5%)

19 (63.3%)

28 (93.3%)

< 0.001*

< 0.001*

0.010*

aMELD score

   

< 0.001*

 Range

(6.4–27)

(9.3–23.2)

(19–41)

I vs II

I vs III

II vs III

 Mean ± SD

11.48 ± 4.63

15.18 ± 3.65

27.52 ± 4.73

0.012*

< 0.001*

< 0.001*

aMELD-Na score

   

< 0.001*

 Range

(9.4–30)

(13.2–25.7)

(22.1–41)

I vs II

I vs III

II vs III

 Mean ± SD

14.79 ± 4.62

19.36 ± 3.03

29.85 ± 4.09

< 0.001*

< 0.001*

< 0.001*

aSerum Na (mEq/l)

   

< 0.001*

 Range

(132–142)

(125–143)

(114–139)

I vs II

I vs III

II vs III

 Mean ± SD

136.5 ± 2.61

135.43 ± 4.08

131.96 ± 5.05

1

0.001*

0.006*

aSerum K (mEq/l)

 Range

(3.5–4.9)

(2.9–5.4)

(2.4–5.7)

0.750

 Mean ± SD

4.31 ± 0.32

4.21 ± 0.52

4.17 ± 0.91

 

aSerum creatinine (mg/dl)

   

< 0.001*

 Range

(0.4–0.7)

(0.4–0.7)

(1.5–4)

I vs II

I vs III

II vs III

 Mean ± SD

0.56 ± 0.07

0.56 ± 0.07

2.31 ± 0.61

1

< 0.001*

< 0.001*

aSerum urea (mg/dl)

   

< 0.001*

 Range

(25–57)

(16–60)

(78–252)

I vs II

I vs III

II vs III

 Mean ± SD

37.49 ± 8.55

40.74 ± 11.65

143.33 ± 54.73

1

< 0.001*

< 0.001*

aGFR (ml/min/1.73m2)

   

< 0.001*

 Range

(106–176)

(102–219)

(16–44)

I vs II

I vs III

II vs III

 Mean ± SD

140.05 ± 18.36

144.56 ± 26.97

26.1 ± 6.62

1

< 0.001*

< 0.001*

bFENa(%)

 Median

0.41

0.35

0.73

0.054

 IR

(0.21–0.68)

(0.22–0.81)

(0.31–0.92)

 

bFEUrea(%)

   

0.001*

 Median

20.25

22.75

10.78

I vs II

I vs III

II vs III

 IR

(16.09–25.67)

(10.77–30.5)

(5.67–18.68)

1

0.018*

0.001*

  1. Bold values indicate significant results
  2. SBP Systolic blood pressure, DBP Diastolic blood pressure, MAP Mean arterial pressure, Hb Hemoglobin, Hct Hematocrit, WBCs White blood cells, ALT Alanine aminotransferase, AST Aspartate transaminase, INR International normalized ratio, CPT Child-Pugh-Turcotte score, MELD Model for end-stage liver disease, MELD-Na Model for end-stage liver disease-sodium, Na Serum sodium, K Serum potassium, GFR Glomerular filtration rate, FeNa Fractional excretion of sodium, FEUrea Fractional excretion of urea
  3. *Significant difference at p-value < 0.05
  4. aOne way ANOVA test for parametric quantitative data between the three groups followed by post hoc Bonferroni correction between each two group
  5. bKruskal-Wallis test for nonparametric quantitative data between the three groups followed by Mann-Whitney test between each two groups and Dunn-Bonferroni post hoc in case of significant Kruskal-Wallis
  6. cChi-square test for qualitative data between groups
  7. dFisher exact test for qualitative data between groups
Back to article page