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Table 1 Comparison between the different studied groups according to demographic data, severity of liver disease, and the mean of investigated parameters and s. Talin-1 level

From: Assessment of serum Talin-1 in liver cirrhosis and hepatocellular carcinoma

 

Early HCC (n=30)

Late HCC (n=30)

Cirrhotic (n=15)

Control (n=15)

Test of Sig.

p

Age (years) Mean ± SD

54.77 ± 9.70

56.13 ± 6.77

53.87 ± 8.41

49.93 ± 11.0

F=1.683

0.177

Sex

No. (%)

No. (%)

No. (%)

No. (%)

  

 Male

24 (80)

26 (86.7)

10 (66.7)

8 (53.3)

χ2=6.706

MCp=0.076

 Female

6 (20)

4 (13.3)

5 (33.3)

7 (46.7)

CHILD score

 A

8 (26.7)

6 (20.0)

0 (0.0)

 

χ2=26.030*

MCp<0.001*

 B

21 (70.0)

8 (26.7)

11 (73.3)

 

 C

1 (3.3)

16 (53.3)

4 (26.7)

 

BCLC score

 A

10 (33.3)

0

  

χ2=60.000

MCp<0.001*

 B

20 (66.7)

0

  

 C

0

13 (43.3)

  

 D

0

17 (56.7)

  

Lab Investigations

 Hb (g/dl)

11.43 ± 1.80

11.44 ± 1.88

10.57 ± 1.78

13.73 ± 1.21

F=9.380*

<0.001*

 WBCs (103)

5.45 ± 2.82

7.69 ± 4.13

5.57 ± 2.80

7.97 ± 1.62

KWχ2= 13.312*

0.004*

 Platelets (103)

111.43±77.54

130.70±93.60

87.20 ± 53.46

317.0 ± 67.35

KWχ2=32.619*

<0.001*

 T. Bilirubin (mg/dl)

1.55 ± 1.08

4.92 ± 6.65

2.39 ± 3.05

0.49 ± 0.2 5

KWχ2=39.160*

<0.001*

 INR

1.40 ± 0.22

1.67 ± 0.40

1.54 ± 0.36

 

F=4.870*

0.01

 S. Albumin (g/dl)

2.81 ± 0.60

2.53 ± 0.91

2.40 ± 0.59

4.35 ± 0.40

F=27.315*

<0.001*

 AFP (ng/ml)

693.9 ± 2216.8

4139.9±21178.5

9.89 ± 9.27

6.02 ± 2.24

KWχ2= 16.476*

0.001*

 S. Talin-1 (ng/ml)

6.77±1.72

10.63±2.13

4.19±1.45

1.42 ± 1.37

F = 102.437*

<0.001*

 pCon

<0.001*

<0.001*

<0.001*

   
  1. F test (ANOVA), χ2 value for chi-square, MC Monte Carlo test, KWχ2 chi-square for Kruskal-Wallis test, *Statistically significant at p ≤ 0.05, pCon: p value for comparing between control and each other group