Effect of direct-acting antiviral drugs on portal circulation hemodynamics in cirrhotic patients infected with HCV

Egyptian Liver Journal

Table 2 Laboratory changes before and after treatment

Chemical changes		Before treatment	After treatment	P
APRI test	Range	0.3–6.3	0.2–2.9	0.001*
APRI test	Mean ± SD	1.4 ± 1.3	0.79 ± 0.84	0.001*
Total bilirubin	Range	1–2	1–4	0.4
Total bilirubin	Mean ± SD	1.11 ± 0.36	1.04 ± 0.75	0.4
ALT	Range	20–94	17–77	0.001*
ALT	Mean ± SD	40 ± 23.4	31.5 ± 19.03	0.001*
AST	Range	24–102	20–87	0.001*
AST	Mean ± SD	46.4 ± 26.6	38.6 ± 22.2	0.001*
Albumin	Range	2.8–4.5	3.5–4.9	0.001*
Albumin	Mean ± SD	3.6 ± 0.47	4.2 ± 0.37	0.001*
INR	Range	1–2	1–2	0.001*
INR	Mean ± SD	1.26 ± 0.29	1.10 ± 0.12	0.001*
PC	Range	42.5–97	50–93	0.001*
PC	Mean ± SD	72.3 ± 19.1	82.9 ± 11.4	0.001*
Platelet count	Range	51–294	86–378	0.001*
Platelet count	Mean ± SD	130.3 ± 55.09	189.5 ± 76.4	0.001*
FIB4	Range	1.06–9.7	0.84–7.4	0.001*
FIB4	Mean ± SD	3.7 ± 2.2	2.5 ± 1.7	0.001*