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Table 1 Univariate and multivariate analysis of predictors of SVR12 in treated patients

From: Efficacy and safety of sofosbuvir and daclatasvir in patients with chronic hepatitis C virus induced cirrhosis with Child-Pugh class B

Parameter Patients who achieved SVR12
N = 92
Patients who failed treatment
N = 15
Univariate analysis Multivariate analysis
P value RR% CI) P value RR
(95% CI)
Age (years)
 Mean ± SD 55.05 ± 8.13 57.8 ± 7.29 0.22 1.0(0.97-1.13)   
 (Min–Max) (36–69) (41–70)     
Gender
 Male 31 (33.7%) 9(60%) 0.06 2.9(0.96-9.05)   
 Female (r) 61 (66.3%) 6(40%)   1   
Prior HCV treatment
 Naïve 72 (78.3%) 12(80%) 0.88 0.9(0.23-3.5)   
 Experienced (r) 20 (21.7%) 3(20%)   1   
Hemoglobin (gm/dl)
 Male: (13.2–17.5 gm/dl) 12.17 ± 1.6 12.02 ± 1.57 0.75 0.9(0.67–1.33)   
 Female: (11.5–16 gm/dl)     1   
WBCs *103/m(4 11 × 103/ml) 4.66 ± 1.6 3.75 ± 1.49 0.05 0.66(0.44–1)
1
0.04 0.64 (0.42–0.98)
Platelet count × 103/ml (150–450 × 103/ml) 94.5 (50–356) 84 (55–142) 0.16 0.99 (0.97–1.004)   
PCR (iu/ml)*103 297.10 (0.135–20223) 437 (9.97–4823) 0.36 1.0 (1.0–1.0)   
ALT/ULN (fold) 1.325 (0.22–5.35) 0.98 (0.48–4.12) 0.35 0.66 (0.27–1.58)   
AST/ULN (fold) 1.765 (0.4–5.85) 1.73 (0.4–4.7) 0.94 0.98 (0.59–1.64)   
Serum Albumin (g/dl) (3.4–5.4 g/dl) 2.8 ± 0.4 2.79 ± 0.26 0.31 0.45(0.09–2.09)   
Serum bilirubin (mg/dl) (0.3–1 mg/dl) 1.42 ± 0.7 1.74 ± 0.87 0.15 1.68 (0.84–3.39)   
I.N.R. (0.9–1.2) 1.32 ± 0.22 1.34 ± 0.18 0.60 1.93 (0.1623.2)   
Serum creatinine (mg/dl)
 Male: (0.6–1.2 mg/dl) 0.85 ± 0.25 0.99 ± 0.41 0.07 4.6 (0.88–23.8)   
 Female: (0.8–1.4 mg/dl)       
AFP (μg/l) (< 8 μg/l) 12.35 (0.1–201) 9 (2.64–83) 0.4 0.98(0.96–1.02)   
MELD score
 Mean ± SD 11 ± 2.97 12.87 ± 2.6     
 (Min-max) (6–17) (8–18)     
 < 10(r) 29 (31.5%) 2(13.3%) 0.15 1   
 ≥ 10 63 (68.5%) 13(86.7%)   2.9(0.63–14.1)   
Ultrasonography
 Liver cirrhosis 92 (100%) 15(100%) 1 Undefined   
 Splenomegaly 55 (59.8%) 6(40%) 0.2 0.45(0.15–1.4)   
 Ascites 44 (47.8%) 11(73.3%) 0.07 3.0(0.89–10.1)   
 Hemangioma 0 (0%) 1(6.67%) 0.15 U`ndefined   
 Ablated HCC 1 (1.09%) 0(0%) 1.0 Undefined   
Child-Pugh score
 B7 67 (72.8%) 6(40%) 0.18 1   1
 B8 20 (21.7%) 6(40%) 0.06 3.4(0.97–11.5) 0.07 3.2(0.9–11.6)
 B9 5 (5.4%) 3(20%) 0.024 6.7(1.3–35.1) 0.016 8.6(1.5–49.8)