Parameter | Patients who achieved SVR12 N = 92 | Patients who failed treatment N = 15 | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|---|---|
P value | RR% CI) | P value | RR (95% CI) | |||
Age (years) | ||||||
Mean ± SD | 55.05 ± 8.13 | 57.8 ± 7.29 | 0.22 | 1.0(0.97-1.13) | ||
(Min–Max) | (36–69) | (41–70) | ||||
Gender | ||||||
Male | 31 (33.7%) | 9(60%) | 0.06 | 2.9(0.96-9.05) | ||
Female (r) | 61 (66.3%) | 6(40%) | 1 | |||
Prior HCV treatment | ||||||
Naïve | 72 (78.3%) | 12(80%) | 0.88 | 0.9(0.23-3.5) | ||
Experienced (r) | 20 (21.7%) | 3(20%) | 1 | |||
Hemoglobin (gm/dl) | ||||||
Male: (13.2–17.5 gm/dl) | 12.17 ± 1.6 | 12.02 ± 1.57 | 0.75 | 0.9(0.67–1.33) | ||
Female: (11.5–16 gm/dl) | 1 | |||||
WBCs *103/m(4 11 × 103/ml) | 4.66 ± 1.6 | 3.75 ± 1.49 | 0.05 | 0.66(0.44–1) 1 | 0.04 | 0.64 (0.42–0.98) |
Platelet count × 103/ml (150–450 × 103/ml) | 94.5 (50–356) | 84 (55–142) | 0.16 | 0.99 (0.97–1.004) | ||
PCR (iu/ml)*103 | 297.10 (0.135–20223) | 437 (9.97–4823) | 0.36 | 1.0 (1.0–1.0) | ||
ALT/ULN (fold) | 1.325 (0.22–5.35) | 0.98 (0.48–4.12) | 0.35 | 0.66 (0.27–1.58) | ||
AST/ULN (fold) | 1.765 (0.4–5.85) | 1.73 (0.4–4.7) | 0.94 | 0.98 (0.59–1.64) | ||
Serum Albumin (g/dl) (3.4–5.4 g/dl) | 2.8 ± 0.4 | 2.79 ± 0.26 | 0.31 | 0.45(0.09–2.09) | ||
Serum bilirubin (mg/dl) (0.3–1 mg/dl) | 1.42 ± 0.7 | 1.74 ± 0.87 | 0.15 | 1.68 (0.84–3.39) | ||
I.N.R. (0.9–1.2) | 1.32 ± 0.22 | 1.34 ± 0.18 | 0.60 | 1.93 (0.1623.2) | ||
Serum creatinine (mg/dl) | ||||||
Male: (0.6–1.2 mg/dl) | 0.85 ± 0.25 | 0.99 ± 0.41 | 0.07 | 4.6 (0.88–23.8) | ||
Female: (0.8–1.4 mg/dl) | ||||||
AFP (μg/l) (< 8 μg/l) | 12.35 (0.1–201) | 9 (2.64–83) | 0.4 | 0.98(0.96–1.02) | ||
MELD score | ||||||
Mean ± SD | 11 ± 2.97 | 12.87 ± 2.6 | ||||
(Min-max) | (6–17) | (8–18) | ||||
< 10(r) | 29 (31.5%) | 2(13.3%) | 0.15 | 1 | ||
≥ 10 | 63 (68.5%) | 13(86.7%) | 2.9(0.63–14.1) | |||
Ultrasonography | ||||||
Liver cirrhosis | 92 (100%) | 15(100%) | 1 | Undefined | ||
Splenomegaly | 55 (59.8%) | 6(40%) | 0.2 | 0.45(0.15–1.4) | ||
Ascites | 44 (47.8%) | 11(73.3%) | 0.07 | 3.0(0.89–10.1) | ||
Hemangioma | 0 (0%) | 1(6.67%) | 0.15 | U`ndefined | ||
Ablated HCC | 1 (1.09%) | 0(0%) | 1.0 | Undefined | ||
Child-Pugh score | ||||||
B7 | 67 (72.8%) | 6(40%) | 0.18 | 1 | 1 | |
B8 | 20 (21.7%) | 6(40%) | 0.06 | 3.4(0.97–11.5) | 0.07 | 3.2(0.9–11.6) |
B9 | 5 (5.4%) | 3(20%) | 0.024 | 6.7(1.3–35.1) | 0.016 | 8.6(1.5–49.8) |