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Table 3 Comparison of studied KIR activating genes and some disease characteristics in AIH-I patients

From: Association of the killer immunoglobulin-like receptor genes KIR2DS1 and KIR2DS4 with pediatric autoimmune hepatitis type I in Egypt

  KIR2DS1 KIR2DS4
+
(N = 68)

(N = 12)
P +
(N = 74)

(N = 6)
P
Anti-nuclear antibodies (ANA)
 Negative 52 (76.5) 12 (100) 0.32 64 (86.5) 0 < 0.001
 Positive 16 (23.5) 0 10 (13.5) 6 (100)
Anti-smooth muscle antibodies (ASMA)
 Negative 10 (14.7) 2 (16.7) 1.00 12 (16.2) 0 1.00
 Positive 58 (85.3) 10 (83.3) 62 (83.8) 6 (100)
Treatment regimen
 Steroid 22 (32.3) 4.(33.3) 1.00 20 (27) 6 (100) 0.008
 Steroid and azathioprine 46 (67.7) 8 (66.7) 54 (73) 0
Treatment response
 Complete remission 40 (58.8) 6 (50) 1.00 40 (54) 6 (100) 0.036
 Relapse 28 (41.2) 6 (50) 34 (46) 0
Hepatitis Activity Index (HAI)
  7.06 ± 2.89 9.83 ± 4.44 0.006 7.22 ± 3.21 10.67 ± 2.31 0.012
Degree of fibrosis
  2.94 ± 1.01 2.67 ± 0.52 0.369 2.84 ± 0.9 3.67 ± 1.53 0.043
  1. Data are given either number (%) or mean ± SD
  2. +, present gene; −, absent gene