Role of bile acids in the prediction of hepatocellular carcinoma in HCV-induced liver cirrhosis

Egyptian Liver Journal

Table 3 Analytical data obtained from ROC curve analysis of 14 Bile acid. The AUC, the cutoff point at the Youden’s index, the sensitivity, and the specificity of each bile acid

BA	NHC vs. HCC				NCLD vs. HCC				CLD vs HCC
BA	AUC	Cutoff	Sen%	Spe%	AUC	Cutoff	Sen%	Spe%	AUC	Cutoff	Sen%	Spe%
CA	0.640	0.005	88	34	0.577	0.35	36	88	0.469	2.9	20	98
CDCA	0.743	0.215	82	62	0.684	0.51	60	76	0.532	3.35	26	92
DCA	0.470	0.55	16	100	0.375	0.365	22	94	0.442	0.045	66	40
LCA	0.792	0.001	76	74	0.614	0.035	50	80	0.638	0.001	76	48
UDCA	0.643	0.12	38	94	0.594	0.325	32	100	0.447	0.325	32	78
GCA	0.889	1.55	78	100	0.859	1.35	78	94	0.626	1.45	78	46
GCDCA	0.948	1.705	84	96	0.910	3.15	74	100	0.584	3.1	74	48
GDCA	0.558	1.015	32	98	0.502	0.405	42	86	0.414	32.2	2	100
GUDCA	0.850	0.22	80	84	0.891	0.15	86	82	0.612	0.215	80	46
TCA	0.859	0.025	74	94	0.795	0.475	60	100	0.563	0.435	60	64
TCDCA	0.963	0.21	96	88	0.966	0.55	84	100	0.635	0.55	84	38
TDCA	0.516	0.375	20	96	0.559	0.11	26	100	0.496	1.025	10	100
TLCA	0.648	0.002	40	86	0.533	0.007	34	96	0.508	0.002	40	70
TUDCA	0.611	0.125	32	94	0.662	0.055	46	88	0.536	0.115	32	96

NHC normal healthy control, NCLD noncirrhotic liver disease, CLD cirrhotic liver diseases, HCC hepatocellular carcinoma, BA bile acid, N = 50, number of each group, ROC receiver operator characteristic, AUC Area under curve, Sen. sensitivity, Spe. specificity. AUC > 0.8 indicates significant relation
CA cholic acid, CDCA chenodeoxycholic acid, DCA deoxycholic acid, LCA lithocholic acid, UDCA ursodeoxycholic acid, GCA glycholic acid, GCDCA glycochenodeoxycholic acid, GDCA glycodeoxycholic acid, GUDCA glycoursodeoxycholic acid, TCA taurocholic acid, TCDCA taurochenodeoxycholic acid, TDCA taurodeoxycholic acid, TLCA taurolithocholic acid, TUDCA tauroursodeoxycholic acid