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Table 3 Analytical data obtained from ROC curve analysis of 14 Bile acid. The AUC, the cutoff point at the Youden’s index, the sensitivity, and the specificity of each bile acid

From: Role of bile acids in the prediction of hepatocellular carcinoma in HCV-induced liver cirrhosis

BA NHC vs. HCC NCLD vs. HCC CLD vs HCC
AUC Cutoff Sen% Spe% AUC Cutoff Sen% Spe% AUC Cutoff Sen% Spe%
CA 0.640 0.005 88 34 0.577 0.35 36 88 0.469 2.9 20 98
CDCA 0.743 0.215 82 62 0.684 0.51 60 76 0.532 3.35 26 92
DCA 0.470 0.55 16 100 0.375 0.365 22 94 0.442 0.045 66 40
LCA 0.792 0.001 76 74 0.614 0.035 50 80 0.638 0.001 76 48
UDCA 0.643 0.12 38 94 0.594 0.325 32 100 0.447 0.325 32 78
GCA 0.889 1.55 78 100 0.859 1.35 78 94 0.626 1.45 78 46
GCDCA 0.948 1.705 84 96 0.910 3.15 74 100 0.584 3.1 74 48
GDCA 0.558 1.015 32 98 0.502 0.405 42 86 0.414 32.2 2 100
GUDCA 0.850 0.22 80 84 0.891 0.15 86 82 0.612 0.215 80 46
TCA 0.859 0.025 74 94 0.795 0.475 60 100 0.563 0.435 60 64
TCDCA 0.963 0.21 96 88 0.966 0.55 84 100 0.635 0.55 84 38
TDCA 0.516 0.375 20 96 0.559 0.11 26 100 0.496 1.025 10 100
TLCA 0.648 0.002 40 86 0.533 0.007 34 96 0.508 0.002 40 70
TUDCA 0.611 0.125 32 94 0.662 0.055 46 88 0.536 0.115 32 96
  1. NHC normal healthy control, NCLD noncirrhotic liver disease, CLD cirrhotic liver diseases, HCC hepatocellular carcinoma, BA bile acid, N = 50, number of each group, ROC receiver operator characteristic, AUC Area under curve, Sen. sensitivity, Spe. specificity. AUC > 0.8 indicates significant relation
  2. CA cholic acid, CDCA chenodeoxycholic acid, DCA deoxycholic acid, LCA lithocholic acid, UDCA ursodeoxycholic acid, GCA glycholic acid, GCDCA glycochenodeoxycholic acid, GDCA glycodeoxycholic acid, GUDCA glycoursodeoxycholic acid, TCA taurocholic acid, TCDCA taurochenodeoxycholic acid, TDCA taurodeoxycholic acid, TLCA taurolithocholic acid, TUDCA tauroursodeoxycholic acid