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Table 3 Laboratory and fibrosis score changes in early and advanced groups

From: Evaluation of long-term changes of aspartate—platelet ratio index, FIB4, and liver stiffness in chronic hepatitis C patients successfully treated by direct-acting antivirals

  Early stage Advanced stage
Baseline Follow-up P value Baseline Follow-up P value
Stiffness 5.9±1.5 5.4±2.2 0.04 18±8.8 15.9 ±7.8 0.077
APRI score 0.42±0.3 0.24±0.1 <0.01 0.85±0.5 0.4±0.2 <0.001
Fib4 1±0.6 0.93±0.5 0.1 2.9±2.3 1.8±1.4 0.002
ALT (IU/L) 53±42 21±10 <0.01 55±37 26±11 <0.001
AST (IU/L) 42±30 24±10 <0.01 58±26 28±11 <0.001
AFP (IU/L) 3.3±2 3.5±1.8 0.5 6±4.2 5.5±3 0.4
Albumin (g/dL) 4.2±0.35 4.1±0.3 0.35 3.9±0.6 3.9±0.4 0.5
Total bilirubin (mg/dL) 0.6±0.2 0.7±0.2 0.2 0.9±0.5 0.86±0.3 0.4
Indirect bilirubin (mg/dL) 0.4±0.4 0.4±0.2 0.7 0.6±0.3 0.5±0.2 0.5
WBCx103/mm3 7±2.4 6.8±1.7 0.3 7.1±1.8 6.7±2.1 0.2
Hb 13.8± 1.6 12.5±1.2 <0.001 13±1.9 12.4±1.5 0.008
plateletsx103/mm3 251.5 ± 58 265 ± 72 0.05 199±80 215±67 0.08
INR 1±0.09 1 ±0.09 0.3 1.12. 1.16 0.1
Creatinine 0.87±0.2 0.85±0.15 0.6 0.8±0.1 0.9±0.1 0.8