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Table 8 C/D ratio in correlation with different genotype of donor when recipient genotype is CT or TT (Mann–Whitney test)

From: Clinical utility of ABCB1 single nucleotide polymorphism on tacrolimus dose requirements in Egyptian liver transplant patients

  Group 3 (CT or TT/CC) Group 4 (CT or TT/CT or TT) U test P-value Sig.
No. = 8 No. = 6
1st wk       
C/D ratio Median (IQR) 115.65(55.55–150.75) 138.7(113.5–160.3) −0.775 0.439 NS
Range 22.5–350 72–294.4
Dose Median (IQR) 0.05(0.04–0.06) 0.04(0.03–0.05) −0.589 0.556 NS
Range 0.01–0.06 0.02–0.09
Trough level Median (IQR) 4.18(1.95–4.95) 5.6(4.2–6.7) −1.678 0.093 NS
Range 0.9–5.8 2.6–7.9
2nd wk       
C/D Median (IQR) 100.25(65.1–126) 121.2(92.5–176.4) −0.711 0.477 NS
Range 33.75–187.5 54.7–740
Dose Median (IQR) 0.06(0.04–0.08) 0.07(0.04–0.1) −0.393 0.694 NS
Range 0.04–0.1 0.01–1.5
Trough level Median (IQR) 5.35(3.5–7.75) 5.65(5–6.3) −0.065 0.948 NS
Range 2.7–9.6 2.7–7.4
3rd wk       
C/D Median (IQR) 76.35(63.92–124) 125.75(98.6–196) −0.904 0.366 NS
Range 58–310 57.3–200.3
Dose Median (IQR) 0.07(0.05–0.07) 0.05(0.04–0.08) −0.327 0.744 NS
Range 0.03–0.1 0.03–0.1
Trough level Median (IQR) 5.35(4–7.7) 6.3(5.5–7.8) −1.033 0.302 NS
Range 2.9–9.3 5.2–15
4th wk       
C/D Median (IQR) 128.6(119.65–191) 114.45(91.4–133) −1.291 0.197 NS
Range 110–250 72.32–326.4
Dose Median (IQR) 0.04(0.02–0.06) 0.07(0.05–0.07) −1.899 0.058 NS
Range 0.02–0.07 0.04–0.09
Trough level Median (IQR) 5.15(4.75–6.55) 7.5(6.1–8.5) −2.200 0.028 S
Range 2.2–8.4 5.46–14.5
2 months       
Dose Median (IQR) 0.04(0.03–0.08) 0.05(0.03–0.1) −0.575 0.565 NS
Range 0.02–0.08 0.03–0.1
Trough level Median (IQR) 6.7(6.4–8.1) 6.2(5.9–6.8) −0.568 0.570 NS
Range 2.2–8.4 5.5–14.6
C/D Median (IQR) 140(94–202) 113(59–226) −0.081 0.935 NS
Range 82.5–213 55–486
3 months       
Dose Median (IQR) 0.04(0.03–0.06) 0.05(0.04–0.07) −0.818 0.414 NS
Range 0.01–0.07 0.02–0.1
Trough level Median (IQR) 5.8(1.5–8.2) 5.8(4.5–6.9) −0.082 0.935 NS
Range 1.4–9.1 4.5–7
C/D Median (IQR) 140(70–150) 112.5(99–127) −0.407 0.684 NS
Range 47–150 58–205
  1. P > 0.05, non-significant; P < 0.05, significant; P < 0.01, highly significant
  2. Group 1 (CC/CC), group 2 (CC/CT or TT), group 3 (CT or TT/CC), and group 4 (CT or TT/CT or TT)