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Egyptian Liver Journal

Table 5 Relation of ABCB1 genotype and C/D ratio and tacrolimus dose and concentration among the donors’ group in relation to ABCB1 genotype (Mann–Whitney test)

From: Clinical utility of ABCB1 single nucleotide polymorphism on tacrolimus dose requirements in Egyptian liver transplant patients

  ABCB1 U test P-value Sig.
CC CT+TT
C/D 1st wk Median (IQR) 70 (34.5–132.5) 131.7 (100–160.3) −2.164 0.030 S
Range 22.5–350 48–294.4
Tac dose (mg/kg/day) Median (IQR) 0.06 (0.04–0.07) 0.04 (0.03–0.09) −0.950 0.342 NS
Range 0.01–0.1 0.01–0.7
Trough level (ng/dl) Median (IQR) 4.14 (2.10–4.60) 5.10 (2.60–6.70) −1.526 0.127 NS
Range 0.9–5.8 1–7.9
C/D 2nd wk Median (IQR) 95.2 (66.3–122.4) 93.85 (56–147.2) −0.055 0.956 NS
Range 33.75–187.5 54.5–740
Tac dose (mg/kg/day) Median (IQR) 0.06 (0.04–0.08) 0.07 (0.05–0.1) −1.092 0.275 NS
Range 0.03–0.1 0.01–4
Trough level (ng/dl) Median (IQR) 4.60 (3.70–8.00) 5.10 (4.45–6.20) −0.361 0.718 NS
Range 2.7–9.6 2.7–7.4
C/D 3rd wk Median (IQR) 78 (61.6–116) 125.75 (98.6–169) −1.609 0.108 NS
Range 38.16–310 57.3–200.3
Tac dose (mg/kg/day) Median (IQR) 0.06 (0.04–0.08) 0.06 (0.04–0.08) −0.168 0.867 NS
Range 0.02–0.1 0.02–5.2
Trough level (ng/dl) Median (IQR) 5.20 (3.60–6.50) 5.75 (5.20–7.80) −0.971 0.331 NS
Range 2.9–9.3 3.16–15
C/D4th wk Median (IQR) 122 (99.5–162) 99.45 (79.0–123.5) 0.998 0.318 NS
Range 62.1–250 70.0–326.0
Tac dose (mg/kg/day) Median (IQR) 0.04 (0.03–0.06) 0.06 (0.04–0.07) −0.926 0.355 NS
Range 0.02–0.2 0.02–4.5
Trough level (ng/dl) Median (IQR) 5.60 (5.00–6.50) 6.10 (4.17–8.50) −0.694 0.487 NS
Range 2.2–8.4 1.4–14.5
  1. P-value >0.05, non-significant (NS); P-value <0.05, significant (S); P-value< 0.01, highly significant (HS)
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