Table 5 Relation of ABCB1 genotype and C/D ratio and tacrolimus dose and concentration among the donors’ group in relation to ABCB1 genotype (Mann–Whitney test)

C/D 1st wk

Median (IQR)

70 (34.5–132.5)

131.7 (100–160.3)

−2.164

0.030

S

Range

22.5–350

48–294.4

Tac dose (mg/kg/day)

Median (IQR)

0.06 (0.04–0.07)

0.04 (0.03–0.09)

−0.950

0.342

NS

Range

0.01–0.1

0.01–0.7

Trough level (ng/dl)

Median (IQR)

4.14 (2.10–4.60)

5.10 (2.60–6.70)

−1.526

0.127

NS

Range

0.9–5.8

1–7.9

C/D 2nd wk

Median (IQR)

95.2 (66.3–122.4)

93.85 (56–147.2)

−0.055

0.956

NS

Range

33.75–187.5

54.5–740

Tac dose (mg/kg/day)

Median (IQR)

0.06 (0.04–0.08)

0.07 (0.05–0.1)

−1.092

0.275

NS

Range

0.03–0.1

0.01–4

Trough level (ng/dl)

Median (IQR)

4.60 (3.70–8.00)

5.10 (4.45–6.20)

−0.361

0.718

NS

Range

2.7–9.6

2.7–7.4

C/D 3rd wk

Median (IQR)

78 (61.6–116)

125.75 (98.6–169)

−1.609

0.108

NS

Range

38.16–310

57.3–200.3

Tac dose (mg/kg/day)

Median (IQR)

0.06 (0.04–0.08)

0.06 (0.04–0.08)

−0.168

0.867

NS

Range

0.02–0.1

0.02–5.2

Trough level (ng/dl)

Median (IQR)

5.20 (3.60–6.50)

5.75 (5.20–7.80)

−0.971

0.331

NS

Range

2.9–9.3

3.16–15

C/D4th wk

Median (IQR)

122 (99.5–162)

99.45 (79.0–123.5)

0.998

0.318

NS

Range

62.1–250

70.0–326.0

Tac dose (mg/kg/day)

Median (IQR)

0.04 (0.03–0.06)

0.06 (0.04–0.07)

−0.926

0.355

NS

Range

0.02–0.2

0.02–4.5

Trough level (ng/dl)

Median (IQR)

5.60 (5.00–6.50)

6.10 (4.17–8.50)

−0.694

0.487

NS

Range

2.2–8.4

1.4–14.5