Table 3 Relation of ABCB1 genotype and C/D ratio and tacrolimus dose and concentration among the recipient group during the first month post transplantation (Mann–Whitney test)

C/D 1st wk

Median (IQR)

48 (39–100)

134.95 (76.6–158)

−2.108

0.035

S

Range

32–221

22.5–350

Tac dose (mg/kg/day)

Median (IQR)

0.07 (0.05–0.1)

0.04 (0.03–0.06)

−2.095

0.036

S

Range

0.01–0.7

0.01–0.09

Trough level (ng/dl)

Median (IQR)

4.14 (1.8–4.9)

4.43 (2.6–5.8)

−0.904

0.366

NS

Range

1–6.8

0.9–7.9

C/D 2nd wk

Median (IQR)

75.5 (66–113.75)

100.25 (75–147.2)

−1.123

0.262

NS

Range

54.5–170

33.75–740

Tac dose (mg/kg/day)

Median (IQR)

0.06 (0.05–0.08)

0.06 (0.04–0.08)

−0.359

0.719

NS

Range

0.03–4

0.01–1.5

Trough level (ng/dl)

Median (IQR)

4.45 (3.7–6.8)

5.6 (3.9–7.4)

−0.411

0.681

NS

Range

2.8–8.5

2.7–9.6

C/D 3rd wk

Median (IQR)

105 (60–116)

106.3 (66.24–137.5)

−0.876

0.381

NS

Range

38.16–169

57.3–310

Tac dose (mg/kg/day)

Median (IQR)

0.05 (0.04–0.09)

0.06 (0.03–0.07)

−0.358

0.720

NS

Range

0.02–4.5

0.02–0.09

Trough level (ng/dl)

Median (IQR)

5.2 (3.6–6.5)

5.8 (4.8–7.8)

−0.849

0.396

NS

Range

3.16–10.4

2.9–15

C/D 4th wk

Median (IQR)

91.2 (70.0–123.5)

122.25 (110–162)

2.1325

0.063

NS

Range

62.1–167

72.32–326.0

Tac dose (mg/kg/day)

Median (IQR)

0.06 (0.04–0.09)

0.06 (0.04–0.07)

−0.111

0.912

NS

Range

0.02–5.2

0.03–0.1

Trough level (ng/dl)

Median (IQR)

5.7 (3–6.1)

5.85 (5–8.4)

−1.233

0.217

NS

Range

1.4–7.75

2.2–14.5