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Table 3 Relation of ABCB1 genotype and C/D ratio and tacrolimus dose and concentration among the recipient group during the first month post transplantation (Mann–Whitney test)

From: Clinical utility of ABCB1 single nucleotide polymorphism on tacrolimus dose requirements in Egyptian liver transplant patients

  ABCB1 Z P-value Sig.
CC CT+TT
C/D 1st wk Median (IQR) 48 (39–100) 134.95 (76.6–158) −2.108 0.035 S
Range 32–221 22.5–350
Tac dose (mg/kg/day) Median (IQR) 0.07 (0.05–0.1) 0.04 (0.03–0.06) −2.095 0.036 S
Range 0.01–0.7 0.01–0.09
Trough level (ng/dl) Median (IQR) 4.14 (1.8–4.9) 4.43 (2.6–5.8) −0.904 0.366 NS
Range 1–6.8 0.9–7.9
C/D 2nd wk Median (IQR) 75.5 (66–113.75) 100.25 (75–147.2) −1.123 0.262 NS
Range 54.5–170 33.75–740
Tac dose (mg/kg/day) Median (IQR) 0.06 (0.05–0.08) 0.06 (0.04–0.08) −0.359 0.719 NS
Range 0.03–4 0.01–1.5
Trough level (ng/dl) Median (IQR) 4.45 (3.7–6.8) 5.6 (3.9–7.4) −0.411 0.681 NS
Range 2.8–8.5 2.7–9.6
C/D 3rd wk Median (IQR) 105 (60–116) 106.3 (66.24–137.5) −0.876 0.381 NS
Range 38.16–169 57.3–310
Tac dose (mg/kg/day) Median (IQR) 0.05 (0.04–0.09) 0.06 (0.03–0.07) −0.358 0.720 NS
Range 0.02–4.5 0.02–0.09
Trough level (ng/dl) Median (IQR) 5.2 (3.6–6.5) 5.8 (4.8–7.8) −0.849 0.396 NS
Range 3.16–10.4 2.9–15
C/D 4th wk Median (IQR) 91.2 (70.0–123.5) 122.25 (110–162) 2.1325 0.063 NS
Range 62.1–167 72.32–326.0
Tac dose (mg/kg/day) Median (IQR) 0.06 (0.04–0.09) 0.06 (0.04–0.07) −0.111 0.912 NS
Range 0.02–5.2 0.03–0.1
Trough level (ng/dl) Median (IQR) 5.7 (3–6.1) 5.85 (5–8.4) −1.233 0.217 NS
Range 1.4–7.75 2.2–14.5