Arctigenin attenuates CCl4-induced hepatotoxicity through suppressing matrix metalloproteinase-2 and oxidative stress

Egyptian Liver Journal

Table 1 Hepatotoxicity markers in all studied groups

	Control	CCl₄	Silymarin	Arctigenin
ALT (U/L)	27.2 ± 8.67	920 ± 137^a****	644 ± 128^a**^b	658 ± 144^a**^b
AST (U/L)	42.1 ± 9.41	1390 ± 262^a****	805 ± 194^a**^b*	753 ± 185^a**^b**
ALP (U/L)	71.5 ± 26.4	169 ± 20.7^a****	106 ± 18.9^b***	119 ± 26.5^a^b*
Total bilirubin (mg/dl)	0.61 ± 0.18	1.82 ± 0.27^a****	1.03 ± 0.25^a^b***	1.11 ± 0.21^a^b*

^a Significantly different from the control group
^b Significantly different from CCl₄ group P values: ^*P ≤ 0.05, ^**P ≤0.01, ^***P ≤ 0.001, ^**** P ≤ 0.0001