Baseline | During treatment | Follow-up | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 month | p value | EOT | p value | 3 months | p value | 6 months | p value | 9 months | p value | ||
Hemoglobin (g/dl) | 11.5 ± 0.91 | 11.2 ± 0.77 | 0.013 | 11.4 ± 0.75 | 0.55 | 11.3 ± 0.69 | 0.45 | 11.3 ± 0.43 | 0.21 | 11.1 ± 0.58 | 0.018 |
Platelets | 153.6 ± 39.4 | 184.1 ± 59.1 | 0.003 | 160.6 ± 36.2 | 0.43 | 157.3 ± 38.9 | 0.69 | 191.8 ± 36.2 | < 0.001 | 179.7 ± 36.2 | 0.005 |
ALT (IU/l) | 45.9 ± 15.2 | 35.8 ± 10.4 | 0.001 | 37.6 ± 7.9 | 0.004 | 34.3 ± 11.1 | < 0.001 | 33.7 ± 12.4 | < 0.001 | 32.6 ± 11.1 | < 0.001 |
AST (IU/l) | 36.8 ± 13.4 | 35.0 ± 7.1 | 0.35 | 33.7 ± 12.4 | 0.33 | 36.9 ± 8.6 | 0.98 | 38.5 ± 10.5 | 0.49 | 37.6 ± 7.9 | 0.64 |
AFP (ng/ml) | 28.4 ± 17.05 | 28.9 ± 17.6 | 0.95 | 31.4 ± 18.9 | 0.54 | 35.3 ± 20.2 | 0.08 | 26.6 ± 14.8 | 0.64 | 22.6 ± 13.02 | 0.13 |
Albumin (g/dl) | 3.23 ± 0.39 | 3.23 ± 0.35 | 0.49 | 3.6 ± 0.38 | 0.001 | 3.5 ± 0.42 | 0.019 | 3.4 ± 0.39 | 0.04 | 3.5 ± 0.45 | 0.004 |
ALP (IU/l) | 132.8 ± 45.1 | 107.6 ± 11.5 | 0.002 | 103.5 ± 48.2 | 0.002 | 99.3 ± 14.9 | < 0.001 | 107.6 ± 11.5 | 0.002 | 99.3 ± 14.9 | < 0.001 |
Bilirubin (mg/dl) | 1.07 ± 0.14 | 1.03 ± 0.15 | 0.28 | 0.99 ± 0.11 | 0.003 | 1.3 ± 1.7 | 0.08 | 0.99 ± 0.16 | 0.04 | 0.99 ± 0.20 | 0.045 |
Urea (mg/dl) | 45.3 ± 16.9 | 40.0 ± 10.6 | 0.18 | 34.9 ± 10.7 | 0.005 | 34.3 ± 9.04 | 0.001 | 34.8 ± 7.7 | 0.005 | 34.6 ± 7.4 | 0.002 |
Creatinine (mg/dl) | 0.91 ± 0.33 | 0.92 ± 0.25 | 0.99 | 0.93 ± 0.159 | 0.72 | 0.93 ± 0.16 | 0.52 | 0.96 ± 0.23 | 0.43 | 0.95 ± 0.24 | 0.65 |
INR | 1.06 ± 0.13 | 0.92 ± 0.19 | < 0.001 | 1.3 ± 1.6 | 0.63 | 0.93 ± 0.19 | 0.002 | 1.04 ± 0.14 | 0.36 | 1.03 ± 0.22 | 0.34 |