| |
Baseline
|
During treatment
|
Follow-up
|
|---|
|
1 month
|
p value
|
EOT
|
p value
|
3 months
|
p value
|
6 months
|
p value
|
9 months
|
p value
|
|---|
|
Hemoglobin (g/dl)
|
11.5 ± 0.91
|
11.2 ± 0.77
|
0.013
|
11.4 ± 0.75
|
0.55
|
11.3 ± 0.69
|
0.45
|
11.3 ± 0.43
|
0.21
|
11.1 ± 0.58
|
0.018
|
|
Platelets
|
153.6 ± 39.4
|
184.1 ± 59.1
|
0.003
|
160.6 ± 36.2
|
0.43
|
157.3 ± 38.9
|
0.69
|
191.8 ± 36.2
|
< 0.001
|
179.7 ± 36.2
|
0.005
|
|
ALT (IU/l)
|
45.9 ± 15.2
|
35.8 ± 10.4
|
0.001
|
37.6 ± 7.9
|
0.004
|
34.3 ± 11.1
|
< 0.001
|
33.7 ± 12.4
|
< 0.001
|
32.6 ± 11.1
|
< 0.001
|
|
AST (IU/l)
|
36.8 ± 13.4
|
35.0 ± 7.1
|
0.35
|
33.7 ± 12.4
|
0.33
|
36.9 ± 8.6
|
0.98
|
38.5 ± 10.5
|
0.49
|
37.6 ± 7.9
|
0.64
|
|
AFP (ng/ml)
|
28.4 ± 17.05
|
28.9 ± 17.6
|
0.95
|
31.4 ± 18.9
|
0.54
|
35.3 ± 20.2
|
0.08
|
26.6 ± 14.8
|
0.64
|
22.6 ± 13.02
|
0.13
|
|
Albumin (g/dl)
|
3.23 ± 0.39
|
3.23 ± 0.35
|
0.49
|
3.6 ± 0.38
|
0.001
|
3.5 ± 0.42
|
0.019
|
3.4 ± 0.39
|
0.04
|
3.5 ± 0.45
|
0.004
|
|
ALP (IU/l)
|
132.8 ± 45.1
|
107.6 ± 11.5
|
0.002
|
103.5 ± 48.2
|
0.002
|
99.3 ± 14.9
|
< 0.001
|
107.6 ± 11.5
|
0.002
|
99.3 ± 14.9
|
< 0.001
|
|
Bilirubin (mg/dl)
|
1.07 ± 0.14
|
1.03 ± 0.15
|
0.28
|
0.99 ± 0.11
|
0.003
|
1.3 ± 1.7
|
0.08
|
0.99 ± 0.16
|
0.04
|
0.99 ± 0.20
|
0.045
|
|
Urea (mg/dl)
|
45.3 ± 16.9
|
40.0 ± 10.6
|
0.18
|
34.9 ± 10.7
|
0.005
|
34.3 ± 9.04
|
0.001
|
34.8 ± 7.7
|
0.005
|
34.6 ± 7.4
|
0.002
|
|
Creatinine (mg/dl)
|
0.91 ± 0.33
|
0.92 ± 0.25
|
0.99
|
0.93 ± 0.159
|
0.72
|
0.93 ± 0.16
|
0.52
|
0.96 ± 0.23
|
0.43
|
0.95 ± 0.24
|
0.65
|
|
INR
|
1.06 ± 0.13
|
0.92 ± 0.19
|
< 0.001
|
1.3 ± 1.6
|
0.63
|
0.93 ± 0.19
|
0.002
|
1.04 ± 0.14
|
0.36
|
1.03 ± 0.22
|
0.34
|
- EOT end of treatment, ALT alanine aminotransferase, AST aspartate aminotransferase, AFP alpha fetoprotein, ALP alkaline phosphatase
