Egyptian Liver Journal

Table 4 Agreement (sensitivity, specificity) for combination of different tumor markers to diagnose HCC

From: Role of annexin A2 and osteopontin for early diagnosis of hepatocellular carcinoma in hepatitis C virus patients

	AUC	P	95% C.I.	Sensitivity	Specificity	PPV	NPV	Accuracy
AFP & OPN	0.853^*	< 0.001^*	0.763 – 0.943	70.0	85.0	82.35	73.91	77.50
AFP & ANXA2	0.958^*	< 0.001^*	0.920 – 0.996	82.50	92.50	91.67	84.09	87.50
OPN & ANXA2	0.954^*	< 0.001^*	0.904 – 1.004	92.50	92.50	92.50	92.50	92.50
AFP & OPN & ANXA2	0.964^*	< 0.001^*	0.925 – 1.003	87.50	92.50	92.11	88.10	90.0

AUC area under a curve, CI confidence intervals, NPV negative predictive value, PPV positive predictive value
^*Statistically significant at p ≤ 0.05

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