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Table 4 Agreement (sensitivity, specificity) for combination of different tumor markers to diagnose HCC

From: Role of annexin A2 and osteopontin for early diagnosis of hepatocellular carcinoma in hepatitis C virus patients

  AUC P 95% C.I. Sensitivity Specificity PPV NPV Accuracy
AFP & OPN 0.853* < 0.001* 0.763 – 0.943 70.0 85.0 82.35 73.91 77.50
AFP & ANXA2 0.958* < 0.001* 0.920 – 0.996 82.50 92.50 91.67 84.09 87.50
OPN & ANXA2 0.954* < 0.001* 0.904 – 1.004 92.50 92.50 92.50 92.50 92.50
AFP & OPN & ANXA2 0.964* < 0.001* 0.925 – 1.003 87.50 92.50 92.11 88.10 90.0
  1. AUC area under a curve, CI confidence intervals, NPV negative predictive value, PPV positive predictive value
  2. *Statistically significant at p ≤ 0.05