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Table 3 Agreement (sensitivity, specificity) for AFP, OPN, and ANXA2 to diagnose HCC

From: Role of annexin A2 and osteopontin for early diagnosis of hepatocellular carcinoma in hepatitis C virus patients

 

AUC

P

95% C.I.

Cutoff

Sensitivity

Specificity

PPV

NPV

Accuracy

AFP (ng/ml)

0.818*

< 0.001*

0.719–0.916

> 6#

77.50

82.50

81.6

78.6

80.0

OPN (ng/ml)

0.739*

< 0.001*

0.621–0.857

> 13.2#

65.0

90.0

86.7

72.0

77.50

ANXA2 (ng/ml)

0.927*

< 0.001*

0.872–0.982

> 10.1#

85.0

85.0

85.0

85.0

85.0

  1. AUC area under a curve, CI confidence intervals, NPV negative predictive value, PPV positive predictive value
  2. *Statistically significant at p ≤ 0.05
  3. #Cut off was done by using Youden index