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Table 3 Univariate and multivariate analysis: comparison between thrombophilic parameters in HCC patients with and without thrombotic complications

From: Thrombophilia in hepatocellular carcinoma

Variables

Univariate

Multivariate

ORs

95% CIs

P value

ORs

95% CIs

P value

PT (s)

13.12

4.64–18.12

0.00

6.78

2.65–10.89

0.00

Prothrombin conc.%

1.54

0.94–3.11

0.18

TT (s)

1.92

0.63–3.81

0.142

Fbg (g/l)

10.37

4.64–18.44

0.00

3.97

2.17–12.34

0.00

APTT (s)

2.27

0.87–3.44

0.085

2.33

0.71–7.75

0.11

Protein C deficiency (%)

11.32

3.45–18.44

0.00

4.81

3.11–10.82

0.00

Protein S deficiency (%)

10.45

4.31–16.85

0.00

4.32

2.98–11.42

0.00

Antithrombin deficiency (%)

8.98

4.21–18.32

0.00

2.71

0.64–1.74

0.068

Increased lipoprotein (a) (mg/l)

3.88

3.13–8.69

< .0001

2.784

2.23–5.36

0.01

Hyperhomocysteinemia (μmol/l)

6.24

3.41–19.24

0.000

7.06

2.15–14.6

0.000

APCR

2.11

1.03–3.07

0.03

2.53

1.12–4.71

0.04

FVL mutation

7.76

3.76–17.19

< .0001

6.12

2.25–15.41

0.0003

  1. Significant difference (P value < 0.05)
  2. ORs odds ratios, CI confidence interval, PT prothrombin time, TT thrombin time, APTT activated partial thromboplastin time, Fbg fibrinogen, APCR activated protein C resistance, FVL mutation factor V Leiden (FVL) mutation