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Table 3 Univariate and multivariate analysis: comparison between thrombophilic parameters in HCC patients with and without thrombotic complications

From: Thrombophilia in hepatocellular carcinoma

Variables Univariate Multivariate
ORs 95% CIs P value ORs 95% CIs P value
PT (s) 13.12 4.64–18.12 0.00 6.78 2.65–10.89 0.00
Prothrombin conc.% 1.54 0.94–3.11 0.18
TT (s) 1.92 0.63–3.81 0.142
Fbg (g/l) 10.37 4.64–18.44 0.00 3.97 2.17–12.34 0.00
APTT (s) 2.27 0.87–3.44 0.085 2.33 0.71–7.75 0.11
Protein C deficiency (%) 11.32 3.45–18.44 0.00 4.81 3.11–10.82 0.00
Protein S deficiency (%) 10.45 4.31–16.85 0.00 4.32 2.98–11.42 0.00
Antithrombin deficiency (%) 8.98 4.21–18.32 0.00 2.71 0.64–1.74 0.068
Increased lipoprotein (a) (mg/l) 3.88 3.13–8.69 < .0001 2.784 2.23–5.36 0.01
Hyperhomocysteinemia (μmol/l) 6.24 3.41–19.24 0.000 7.06 2.15–14.6 0.000
APCR 2.11 1.03–3.07 0.03 2.53 1.12–4.71 0.04
FVL mutation 7.76 3.76–17.19 < .0001 6.12 2.25–15.41 0.0003
  1. Significant difference (P value < 0.05)
  2. ORs odds ratios, CI confidence interval, PT prothrombin time, TT thrombin time, APTT activated partial thromboplastin time, Fbg fibrinogen, APCR activated protein C resistance, FVL mutation factor V Leiden (FVL) mutation