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Table 1 Laboratory data between the three studied groups

From: Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus

 

Control (group I) n = 30

HCV-positive antibodies (group II)

Test P value

P1

P2

P3

Group IIa (negative PCR)

n = 30

Group IIb (positive PCR)

n= 30

Liver and renal function test

 Serum total bilirubin (mg/dL)

0.59 ± 0.13

0.79 ± 0.12

1.10 ± 0.22

ANOVA=21.3

0.0001*

0.001*

0.002*

0.005*

 Serum alanine transaminase (ALT) (U/L)

24.67 ± 6.55

40.17 ± 9.62

50.77 ± 9.74

ANOVA=28.62

0.001*

0.0025*

0.0014*

0.004*

 Serum aspartate transaminase (AST) (U/L)

25.13 ± 4.50

33.93 ± 6.65

46.13 ± 9.37

ANOVA=17.85

0.001*

0.015*

0.0025*

0.0036*

 Serum albumin (g/dL)

4.74 ± 0.41

3.73 ± 0.32

3.36 ± 0.52

ANOVA=25.6

0.0001*

0.0016*

0.008*

0.001*

 Blood urea nitrogen (BUN) (mg/dL)

10.53 ± 1.96

10.53 ± 1.41

11.93 ± 2.03

ANOVA=19.85

0.001*

0.500 N.S.

0.004*

0.0014*

 Serum creatinine (mg/dL or μMol/L)

0.76 ± 0.10

67.18 ± 8.51

0.86 ± 0.13

76.15 ± 11.32

0.98 ± 0.22

86.41 ± 19.59

ANOVA=24.2

0.0002*

0.0049*

0.006*

0.0179*

 Creatinine clearance (mL/min)

116.67 ± 12.72

103.33 ± 16.83

89.20 ± 12.90

ANOVA=14.52

0.006*

0.085 N.S.

0.037*

0.00028*

 Urine albumin/creatinine ratio (mg/g)

19.30 ± 3.04

27.04 ± 4.71

30.40 ± 6.17

ANOVA=36.52

0.0001*

0.0011*

0.0031*

0.0104*

Extrahepatic renal affection parameters

 Serum cryoglobulins (ng/mL)

N.D.

125.07 ± 25.7

240.63 ± 11.27

T = 6.81

0.0001*

 

 Serum complement C3 (mg/dL)

133.43 ± 24.42

89.57 ± 9.88

68.37 ± 7.77

ANOVA=33.6

0.0001*

0.001*

0.001*

0.011*

 Serum rheumatoid factor (IU/mL)

7.75 ± 2.02

31.28 ± 19.01

94.92 ± 31.22

ANOVA=42.1

0.0001*

0.0001*

0.0001*

0.004*

 Serum cystatin C (mg/L)

0.66 ± 0.22

1.19 ± 0.22

1.57 ± 0.31

ANOVA=19.25

0.001*

0.002*

0.001*

0.006*

 Serum creatinine/cystatin C ratio (μMol/mg)

99.60 ± 31.03

70.98 ± 16.67

55.07 ± 17.25

ANOVA=27.9

<0.001*

<0.001*

<0.001*

0.03*

  1. P1: comparison between the control group and group IIa. P2: comparison between the control group and group IIb. P3: comparison between groups IIa and IIb
  2. *P was significant if < 0.05