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Table 9 Concentration of lipid profile and IMT at baseline and 6-month follow-up after initiation of anti-HCV therapy in studied cases categorized according to whether or not they achieved SVR

From: Assessment of carotid atherosclerosis in Egyptian chronic hepatitis C patients after treatment by direct-acting antiviral drugs

  Non-SVR
(no. = 3)
SVR
(no. = 77)
Test valuea p-valuea
Mean  ± SD Median Mean  ± SD Median
TC (mg/dL)
Baseline 180.67 18.45 176.00 175.69 39.70 165.00 1.17 0.243
Follow-up 181.33 18.23 178.00 200.69 39.70 190.00 1.04 0.298
p-valueb 0.655  < 0.001  
TGs (mg/dL)
Baseline 129.67 23.59 132.00 126.68 21.26 121.00 0.076 0.939
Follow-up 132.33 30.44 120.00 141.68 21.26 136.00 1.05 0.293
p-valueb 1.00  < 0.001   
LDL (mg/dL)
Baseline 103.00 7.00 106.00 100.44 8.43 101.00 0.827 0.402
Follow-up 105.33 5.86 103.00 117.44 8.43 118.00 2.12 0.034
p-valueb 1.00  < 0.001   
HDL (mg/dL)
Baseline 48.00 3.61 47.00 48.00 4.28 48.00 0.216 0.829
Follow-up 50.00 9.64 46.00 57.00 4.28 57.00 1.36 0.173
p-valueb 1.00  < 0.001  
Carotid IMT
Baseline 1.97 0.20 1.98 1.56 0.74 1.35 1.51 0.132
Follow-up 2.11 0.37 1.92 1.20 0.55 1.06 2.42 0.016
p-valueb 0.285  < 0.001  
  1. p ≤ 0.05 is considered statistically significant; p ≤ 0.01 is considered highly statistically significant. aMann-Whitney U-test. bWilcoxon signed-rank test. SD Standard deviation, TC Total cholesterol, TGs Triglycerides. In non-SVR patients, there was no statistically significant difference in total cholesterol, triglycerides, LDL, and HDL at baseline and follow-up (p > 0.05), while in SVR group, total cholesterol, triglycerides, LDL, and HDL were significantly increased after follow-up compared to baseline (p < 0.001). It was noticed that LDL was significantly higher in SVR group compared to non-SVR after treatment (p = 0.034). Also, carotid IMT was significantly lower in SVR group compared to non-SVR (p = 0.016)