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Egyptian Liver Journal

Table 2 Comparison between laboratory data and IMT before treatment and 6 months after treatment

From: Assessment of carotid atherosclerosis in Egyptian chronic hepatitis C patients after treatment by direct-acting antiviral drugs

 

Baseline

Follow-up

Test valuea

p-value

Mean

 ± SD

Median

Mean

 ± SD

Median

Hb (g/dL)

11.89

1.32

11.55

11.85

1.48

11.50

0.227

0.821

WBCs (109/L)

5.26

1.38

4.80

5.32

1.36

4.80

0.241

0.809

Platelets (109/L)

178.85

51.93

183.00

204.60

53.70

210.00

8.77

 < 0.001

TC (mg/dL)

175.88

39.06

165.00

199.96

39.22

189.50

8.83

 < 0.001

TGs (mg/dL)

126.79

21.19

121.00

141.32

21.48

133.50

8.45

 < 0.001

LDL (mg/dL)

100.54

8.35

101.50

116.99

8.63

118.00

8.82

 < 0.001

HDL (mg/dL)

48.00

4.23

48.00

56.74

4.66

57.00

8.82

 < 0.001

ALT (IU/L)

58.85

15.64

56.00

36.40

9.27

35.50

7.67

 < 0.001

AST (IU/L)

62.47

17.63

57.50

41.89

12.38

39.50

7.13

 < 0.001

Albumin (g/dL)

3.46

0.66

3.27

3.64

0.66

3.45

8.45

 < 0.001

Bilirubin (mg/dl)

1.36

0.41

1.36

1.27

0.46

1.25

7.51

 < 0.001

INR

1.28

0.28

1.17

1.22

0.31

1.10

7.19

 < 0.001

HCV RNA

812,219.3

730,374.3

659,500.0

30,062.50

165,954.3

0.00

7.65

 < 0.001

AFP (ng/mL)

9.88

6.25

9.30

9.26

5.91

8.25

0.722

0.470

S. creatinine (mg/dl)

0.94

0.18

0.90

0.92

0.18

0.90

0.609

0.542

Blood urea (mg/dl)

21.45

7.83

19.00

22.73

9.44

19.50

0.887

0.375

RBS (mg/dl)

146.19

60.39

126.00

130.00

31.25

121.00

8.61

 < 0.001

IMT

1.57

0.73

1.36

1.24

0.57

1.07

7.823

 < 0.001

  1. p ≤ 0.05 is considered statistically significant; p ≤ 0.01 is considered highly statistically significant. aWilcoxon signed-rank test. SD Standard deviation, TC Total cholesterol, TGs Triglycerides, p ≤ 0.05 is considered statistically significant, p ≤ 0.01 is considered highly statistically significant, AFP Alpha-fetoprotein, RBS Random blood sugar, IMT Intima-media thickness. On comparing laboratory data before starting treatment and 6-month follow-up after treatment, it was noticed that platelets, total cholesterol, triglycerides, LDL, HDL, and albumin were significantly increased after treatment, while ALT, AST, bilirubin, INR, and RBS were significantly decreased after treatment. There was no statistically significant difference in Hb, WBCs, AFP, serum creatinine, and urea. Regarding HCV RNA, 96.25% became negative 6 months after treatment with DAAs. IMT was significantly decreased 6 months after treatment 1.24 vs. 1.57 mm p < 0.001
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