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Table 2 Comparison between laboratory data and IMT before treatment and 6 months after treatment

From: Assessment of carotid atherosclerosis in Egyptian chronic hepatitis C patients after treatment by direct-acting antiviral drugs

  Baseline Follow-up Test valuea p-value
Mean  ± SD Median Mean  ± SD Median
Hb (g/dL) 11.89 1.32 11.55 11.85 1.48 11.50 0.227 0.821
WBCs (109/L) 5.26 1.38 4.80 5.32 1.36 4.80 0.241 0.809
Platelets (109/L) 178.85 51.93 183.00 204.60 53.70 210.00 8.77  < 0.001
TC (mg/dL) 175.88 39.06 165.00 199.96 39.22 189.50 8.83  < 0.001
TGs (mg/dL) 126.79 21.19 121.00 141.32 21.48 133.50 8.45  < 0.001
LDL (mg/dL) 100.54 8.35 101.50 116.99 8.63 118.00 8.82  < 0.001
HDL (mg/dL) 48.00 4.23 48.00 56.74 4.66 57.00 8.82  < 0.001
ALT (IU/L) 58.85 15.64 56.00 36.40 9.27 35.50 7.67  < 0.001
AST (IU/L) 62.47 17.63 57.50 41.89 12.38 39.50 7.13  < 0.001
Albumin (g/dL) 3.46 0.66 3.27 3.64 0.66 3.45 8.45  < 0.001
Bilirubin (mg/dl) 1.36 0.41 1.36 1.27 0.46 1.25 7.51  < 0.001
INR 1.28 0.28 1.17 1.22 0.31 1.10 7.19  < 0.001
HCV RNA 812,219.3 730,374.3 659,500.0 30,062.50 165,954.3 0.00 7.65  < 0.001
AFP (ng/mL) 9.88 6.25 9.30 9.26 5.91 8.25 0.722 0.470
S. creatinine (mg/dl) 0.94 0.18 0.90 0.92 0.18 0.90 0.609 0.542
Blood urea (mg/dl) 21.45 7.83 19.00 22.73 9.44 19.50 0.887 0.375
RBS (mg/dl) 146.19 60.39 126.00 130.00 31.25 121.00 8.61  < 0.001
IMT 1.57 0.73 1.36 1.24 0.57 1.07 7.823  < 0.001
  1. p ≤ 0.05 is considered statistically significant; p ≤ 0.01 is considered highly statistically significant. aWilcoxon signed-rank test. SD Standard deviation, TC Total cholesterol, TGs Triglycerides, p ≤ 0.05 is considered statistically significant, p ≤ 0.01 is considered highly statistically significant, AFP Alpha-fetoprotein, RBS Random blood sugar, IMT Intima-media thickness. On comparing laboratory data before starting treatment and 6-month follow-up after treatment, it was noticed that platelets, total cholesterol, triglycerides, LDL, HDL, and albumin were significantly increased after treatment, while ALT, AST, bilirubin, INR, and RBS were significantly decreased after treatment. There was no statistically significant difference in Hb, WBCs, AFP, serum creatinine, and urea. Regarding HCV RNA, 96.25% became negative 6 months after treatment with DAAs. IMT was significantly decreased 6 months after treatment 1.24 vs. 1.57 mm p < 0.001