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Egyptian Liver Journal

Table 1 Demographic and clinical characteristics of HCV and HCC patients

From: The impact of polymorphism in PNPLA3 and TM6SF2 genes on the susceptibility and survival of hepatitis C-related hepatocellular carcinoma

 

HCV

N=144

HCC

N=120

P value

Demographic data

Age (years)

46.8±9.8

61.5±7.2

0.001**

Gender

Female

71 (49.3%)

30 (25.0%)

0.001**

Male

73 (50.7%)

90 (75.0%)

Smoker

14 (9.7%)

34 (28.3%)

0.001**

Diabetes

26 (18.1%)

33 (27.5%)

0.04*

BMI

28.7±4.0

27.8±5.4

0.1

Laboratory investigation

Hb

13.5±1.6

12.9±2.0

0.01*

WBC

5.9±1.9

6.7±2.8

0.2

Platelets

180.1±65.7

159.4±71.9

0.01*

INR

1.0±0.1

1.2±0.3

0.001**

ALT

60.0 (41.0–86.0)

50.0 (31.0–75.8)

0.01*

AST

61.0 (43.0–87.0)

58.5 (35.0–80.5)

0.2

Alb

3.9±0.6

3.6±0.6

0. 01*

Bil.T

0.8 (0.6–1.0)

0.96 (0.7–1.4)

0.001**

AFP

6.0 (2.8–12.6)

61.2 (9.6–242.1)

0.001**

Crea.

0.9±0.5

0.9±0.2

0.5

HCV F. grades

F1

43 (29.9%)

29 (24.2%)

0.3

F2

27 (18.8%)

7 (5.8%)

0.01*

F3

42 (29.2%)

11 (9.2%)

0.001**

F4

32 (22.2%)

73 (60.8%)

0.001**

BCLC stages

Early

-

56 (46.7%)

-

Intermediate

-

44 (36.7%)

-

Late

-

16 (13.3%)

-

Advanced

-

4 (3.3%)

-

  1. Age, body mass index (BMI), hemoglobin (Hb), white blood cells (WBC), platelets, international normalized ratio (INR), albumin (Alb), and creatinine (Crea) are represented as the mean ± SD; the data were analyzed by Student’s t test. While ALT, AST, total bilirubin (Bil.T), and AFP are represented as the median with interquartile range (25–75%), the data were analyzed by Mann-Whitney U test and gender, smoker, DM, and HCV F. grades/BCLC stages are represented as frequency and percent; the data were analyzed by X2 test
  2. *P value ≤ 0.05 significant; **P value ≤ 0.01 highly significant
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