Skip to main content

Table 2 Comparison between baseline (week 0) and Δ change in laboratory investigations from baseline at weeks 4, 8, and 12 as regards blood counts and liver function tests

From: Study the response of Qurevo (ombitasvir, paritaprevir, and ritonavir) in end-stage renal disease patients with hepatitis C virus

Laboratory investigations Baseline (week 0) Week 4 Week 8 Week 12
WBC (103/ml)
 Mean ± SD 6.648 ± 2.947 6.759 ± 2.741 6.695 ± 3.641 6.530 ± 2.371
 Range (2.7– 20.7) (3.5–16.2) (3.2–27.43) (3.5–14.2)
 Δ change
  Mean ± SD   0.111 ± 2.917 0.047 ± 4.189  − 0.118 ± 2.958
  P-value   0.789 0.938 0.780
HGB (g/dl)
 Mean ± SD 12.050 ± 1.835 10.282 ± 1.962 9.278 ± 1.747 8.959 ± 1.728
 Range (10–16.2) (7–13.9) (6.4–13) (4.2–12.4)
 Δ change
  Mean ± SD    − 1.768 ± 2.168  − 2.772 ± 2.309  − 3.091 ± 2.248
  P-value    < 0.001*  < 0.001*  < 0.001*
PLT (103/ml)
 Mean ± SD 208.820 ± 62.666 216.860 ± 84.864 224.300 ± 65.347 229.380 ± 84.586
 Range (108–372) (92–589) (105–437) (114–570)
 Δ change
  Mean ± SD   8.040 ± 88.070 15.480 ± 63.499 20.560 ± 86.368
  P-value   0.522 0.091 0.099
Total bilirubin (mg/dl)
 Mean ± SD 0.543 ± 0.171 0.770 ± 0.404 0.635 ± 0.257 0.664 ± 0.315
 Range (0.19–1) (0.3–2.5) (0.1–1.5) (0.11.9)
 Δ change
  Mean ± SD   0.227 ± 0.443 0.092 ± 0.278 0.121 ± 0.328
  P-value   0.001* 0.023* 0.012*
Direct bilirubin (mg/dl)
 Mean ± SD 0.351 ± 0.353 0.270 ± 0.206 0.245 ± 0.190 0.238 ± 0.169
 Range (0–1.3) (0–0.98) (0–0.98) (0.03–0.8)
 Δ change
  Mean ± SD    − 0.081 ± 0.404  − 0.106 ± 0.379  − 0.113 ± 0.392
  P-value   0.164 0.054 0.048*
Serum albumin (g/dl)
 Mean ± SD 3.866 ± 0.560 4.018 ± 0.555 3.860 ± 0.589 3.864 ± 0.448
 Range (2–5.1) (2.7–5.3) (2–5.4) (2.8–4.8)
 Δ change
  Mean ± SD   0.152 ± 0.770  − 0.006 ± 0.669  − 0.002 ± 0.563
  P-value   0.169 0.950 0.980
INR
 Mean ± SD 1.112 ± 0.114 1.083 ± 0.146 1.092 ± 0.113 1.069 ± 0.102
 Range (0.88–1.4) (0.9–1.87) (0.77–1.31) (0.88–1.36)
 Δ change
  Mean ± SD    − 0.029 ± 0.172  − 0.020 ± 0.145  − 0.043 ± 0.136
  P-value   0.240 0.338 0.030*
AST (IU/l)
 Mean ± SD 35.634 ± 33.177 27.440 ± 17.126 26.280 ± 12.876 29.350 ± 16.783
 Range (2–222) (6–84) (8–52) (6–94)
 Δ change
  Mean ± SD    − 8.194 ± 31.806  − 9.354 ± 32.381  − 6.284 ± 31.124
  P-value   0.075 0.046* 0.160
ALT (IU/l)
 Mean ± SD 34.736 ± 20.096 19.060 ± 13.549 14.390 ± 5.830 17.422 ± 10.136
 Range (9–94) (4–64) (4–30) (5–64)
 Δ change
  Mean ± SD    − 15.676 ± 19.446  − 20.346 ± 19.962  − 17.314 ± 19.893
  P-value    < 0.001*  < 0.001*  < 0.001*
  1. WBC white blood cell count, HGB hemoglobin level, PLT platelet count, INR international normalized ratio, AST aspartate transaminase, ALT alanine transaminase
  2. * highly significant