|
Laboratory investigations
|
Baseline (week 0)
|
Week 4
|
Week 8
|
Week 12
|
|---|
|
WBC (103/ml)
|
|
Mean ± SD
|
6.648 ± 2.947
|
6.759 ± 2.741
|
6.695 ± 3.641
|
6.530 ± 2.371
|
|
Range
|
(2.7– 20.7)
|
(3.5–16.2)
|
(3.2–27.43)
|
(3.5–14.2)
|
|
Δ change
|
|
Mean ± SD
| |
0.111 ± 2.917
|
0.047 ± 4.189
|
− 0.118 ± 2.958
|
|
P-value
| |
0.789
|
0.938
|
0.780
|
|
HGB (g/dl)
|
|
Mean ± SD
|
12.050 ± 1.835
|
10.282 ± 1.962
|
9.278 ± 1.747
|
8.959 ± 1.728
|
|
Range
|
(10–16.2)
|
(7–13.9)
|
(6.4–13)
|
(4.2–12.4)
|
|
Δ change
|
|
Mean ± SD
| |
− 1.768 ± 2.168
|
− 2.772 ± 2.309
|
− 3.091 ± 2.248
|
|
P-value
| |
< 0.001*
|
< 0.001*
|
< 0.001*
|
|
PLT (103/ml)
|
|
Mean ± SD
|
208.820 ± 62.666
|
216.860 ± 84.864
|
224.300 ± 65.347
|
229.380 ± 84.586
|
|
Range
|
(108–372)
|
(92–589)
|
(105–437)
|
(114–570)
|
|
Δ change
|
|
Mean ± SD
| |
8.040 ± 88.070
|
15.480 ± 63.499
|
20.560 ± 86.368
|
|
P-value
| |
0.522
|
0.091
|
0.099
|
|
Total bilirubin (mg/dl)
|
|
Mean ± SD
|
0.543 ± 0.171
|
0.770 ± 0.404
|
0.635 ± 0.257
|
0.664 ± 0.315
|
|
Range
|
(0.19–1)
|
(0.3–2.5)
|
(0.1–1.5)
|
(0.11.9)
|
|
Δ change
|
|
Mean ± SD
| |
0.227 ± 0.443
|
0.092 ± 0.278
|
0.121 ± 0.328
|
|
P-value
| |
0.001*
|
0.023*
|
0.012*
|
|
Direct bilirubin (mg/dl)
|
|
Mean ± SD
|
0.351 ± 0.353
|
0.270 ± 0.206
|
0.245 ± 0.190
|
0.238 ± 0.169
|
|
Range
|
(0–1.3)
|
(0–0.98)
|
(0–0.98)
|
(0.03–0.8)
|
|
Δ change
|
|
Mean ± SD
| |
− 0.081 ± 0.404
|
− 0.106 ± 0.379
|
− 0.113 ± 0.392
|
|
P-value
| |
0.164
|
0.054
|
0.048*
|
|
Serum albumin (g/dl)
|
|
Mean ± SD
|
3.866 ± 0.560
|
4.018 ± 0.555
|
3.860 ± 0.589
|
3.864 ± 0.448
|
|
Range
|
(2–5.1)
|
(2.7–5.3)
|
(2–5.4)
|
(2.8–4.8)
|
|
Δ change
|
|
Mean ± SD
| |
0.152 ± 0.770
|
− 0.006 ± 0.669
|
− 0.002 ± 0.563
|
|
P-value
| |
0.169
|
0.950
|
0.980
|
|
INR
|
|
Mean ± SD
|
1.112 ± 0.114
|
1.083 ± 0.146
|
1.092 ± 0.113
|
1.069 ± 0.102
|
|
Range
|
(0.88–1.4)
|
(0.9–1.87)
|
(0.77–1.31)
|
(0.88–1.36)
|
|
Δ change
|
|
Mean ± SD
| |
− 0.029 ± 0.172
|
− 0.020 ± 0.145
|
− 0.043 ± 0.136
|
|
P-value
| |
0.240
|
0.338
|
0.030*
|
|
AST (IU/l)
|
|
Mean ± SD
|
35.634 ± 33.177
|
27.440 ± 17.126
|
26.280 ± 12.876
|
29.350 ± 16.783
|
|
Range
|
(2–222)
|
(6–84)
|
(8–52)
|
(6–94)
|
|
Δ change
|
|
Mean ± SD
| |
− 8.194 ± 31.806
|
− 9.354 ± 32.381
|
− 6.284 ± 31.124
|
|
P-value
| |
0.075
|
0.046*
|
0.160
|
|
ALT (IU/l)
|
|
Mean ± SD
|
34.736 ± 20.096
|
19.060 ± 13.549
|
14.390 ± 5.830
|
17.422 ± 10.136
|
|
Range
|
(9–94)
|
(4–64)
|
(4–30)
|
(5–64)
|
|
Δ change
|
|
Mean ± SD
| |
− 15.676 ± 19.446
|
− 20.346 ± 19.962
|
− 17.314 ± 19.893
|
|
P-value
| |
< 0.001*
|
< 0.001*
|
< 0.001*
|
- WBC white blood cell count, HGB hemoglobin level, PLT platelet count, INR international normalized ratio, AST aspartate transaminase, ALT alanine transaminase
- * highly significant
